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学科主题: 临床医学
题名:
Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer
作者: Liu Qiang1; Su Yu2; Jiang Guan-chao1; Zhou Zu-li1; Liu Bao-cai2; Bu Liang1; Yang Fan1; Qiao Fang2; Wang Jun1
关键词: CMTM7 gene ; tumor suppressor gene ; non-small cell lung cancer ; survival
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-08-20
DOI: 10.3760/cmaj.issn.0366-6999.20123625
卷: 126, 期:16, 页:3006-3012
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: P16(INK4A) OVEREXPRESSION ; PROGNOSTIC-SIGNIFICANCE ; CARCINOMA ; P16 ; METHYLATION ; APOPTOSIS ; GENES ; IDENTIFICATION ; TRANSCRIPTION ; MUTATIONS
英文摘要:

Background CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) located at 3p22.3, is a frequent deletion site and a tumor suppressor gene (TSG) locus in many cancer, which suggests CMTM7 may be a potential TSG. The aim of this study was to investigate the correlations of CMTM7 expression and survival rate in patients with non-small-cell lung cancer (NSCLC).

Methods Surgical specimens of 180 cases with pathologically confirmed NSCLC were grouped into 18 tissue microarray slides. CMTM7 expression in these specimens were detected by immunohistochemistry staining and representative cases were confirmed by Western blotting. Univariate and multivariate analyses were performed to identify the association of CMTM7 expression with pathological features and survival of patients with NSCLC.

Results A total of 78.9% of the 180 patients had variations of CMTM7 protein expression, either up-regulated or down-regulated. Univariate analysis showed that the patients′ survival rate after surgery was highly correlated with CMTM7 expression (P=0.0091). In addition, prognostic factors were examined by multivariate Cox regression analysis, and results suggested that CMTM7 expression was a unique prognostic factor in NSCLC survival.

Conclusions The CMTM7 expression may be related to survival of patients with NSCLC and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.

语种: 英语
WOS记录号: WOS:000327916100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60077
Appears in Collections:北京大学第二临床医学院_胸外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing 100044, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Key Lab Med Immunol, Sch Basic Med Sci,Hlth Sci Ctr,Minist Hlth,Dept I, Beijing 100191, Peoples R China

Recommended Citation:
Liu Qiang,Su Yu,Jiang Guan-chao,et al. Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer[J]. CHINESE MEDICAL JOURNAL,2013,126(16):3006-3012.
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