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Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer
Liu Qiang1; Su Yu2; Jiang Guan-chao1; Zhou Zu-li1; Liu Bao-cai2; Bu Liang1; Yang Fan1; Qiao Fang2; Wang Jun1
关键词CMTM7 gene tumor suppressor gene non-small cell lung cancer survival
刊名CHINESE MEDICAL JOURNAL
2013-08-20
DOI10.3760/cmaj.issn.0366-6999.20123625
126期:16页:3006-3012
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]P16(INK4A) OVEREXPRESSION ; PROGNOSTIC-SIGNIFICANCE ; CARCINOMA ; P16 ; METHYLATION ; APOPTOSIS ; GENES ; IDENTIFICATION ; TRANSCRIPTION ; MUTATIONS
英文摘要

Background CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) located at 3p22.3, is a frequent deletion site and a tumor suppressor gene (TSG) locus in many cancer, which suggests CMTM7 may be a potential TSG. The aim of this study was to investigate the correlations of CMTM7 expression and survival rate in patients with non-small-cell lung cancer (NSCLC).

Methods Surgical specimens of 180 cases with pathologically confirmed NSCLC were grouped into 18 tissue microarray slides. CMTM7 expression in these specimens were detected by immunohistochemistry staining and representative cases were confirmed by Western blotting. Univariate and multivariate analyses were performed to identify the association of CMTM7 expression with pathological features and survival of patients with NSCLC.

Results A total of 78.9% of the 180 patients had variations of CMTM7 protein expression, either up-regulated or down-regulated. Univariate analysis showed that the patients′ survival rate after surgery was highly correlated with CMTM7 expression (P=0.0091). In addition, prognostic factors were examined by multivariate Cox regression analysis, and results suggested that CMTM7 expression was a unique prognostic factor in NSCLC survival.

Conclusions The CMTM7 expression may be related to survival of patients with NSCLC and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.

语种英语
WOS记录号WOS:000327916100002
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60077
专题北京大学第二临床医学院_骨关节科
北京大学基础医学院
北京大学第二临床医学院_胸外科
作者单位1.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing 100044, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Key Lab Med Immunol, Sch Basic Med Sci,Hlth Sci Ctr,Minist Hlth,Dept I, Beijing 100191, Peoples R China
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GB/T 7714
Liu Qiang,Su Yu,Jiang Guan-chao,et al. Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer[J]. CHINESE MEDICAL JOURNAL,2013,126(16):3006-3012.
APA Liu Qiang.,Su Yu.,Jiang Guan-chao.,Zhou Zu-li.,Liu Bao-cai.,...&Wang Jun.(2013).Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.CHINESE MEDICAL JOURNAL,126(16),3006-3012.
MLA Liu Qiang,et al."Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer".CHINESE MEDICAL JOURNAL 126.16(2013):3006-3012.
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