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Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study
Xie, Zheng1; Lin, Haijiang2; Fang, Renfei1; Shen, Weiwei2; Li, Shuguang3; Chen, Bo3
关键词Coke oven workers 1-hydroxypyrene (1-OHP) Oxidative stress Genetic damage Fruit-vegetable dietary pattern
刊名ENVIRONMENTAL HEALTH
2015-05-06
DOI10.1186/s12940-015-0028-5
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者Shanghai Natural Science Foundation ; Doctoral Fund of Ministry of Education of China ; Shanghai Natural Science Foundation ; Doctoral Fund of Ministry of Education of China
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; MICRONUCLEUS CYTOME ASSAY ; DNA-DAMAGE ; POLYMORPHISMS ; EMISSIONS ; EXPOSURE ; BLOOD ; RISK ; FOOD ; AIR
英文摘要

Background: Coke oven workers (COWs) are exposed to high level of genotoxic chemicals that induce oxidative stress and genetic damage. The dietary intake of certain types of foods may reverse these effects.

Methods: We conducted a cross-sectional study with 51 topside COWs, 79 other COWs, and 67 controls, to assess the effects of dietary patterns on oxidative stress and genetic damage.

Results: Compared to the controls, both topside and other COWs had significantly higher urinary 1-hydroxypyrene levels, serum oxidant levels [malondialdehyde, (MDA)], and genetic damage [micronucleus (MN) frequency & 8-oxo-2′-deoxyguanosine (8-OH-dG)], but lower antioxidant levels [superoxide dismutase (SOD) and glutathione peroxidase, (GPx)]. The fruit-vegetable (FV) dietary pattern was positively correlated with serum SOD levels and negative correlated with serum MDA, MN frequency, and urinary 8-OH-dG. COWs with an FV patter in the highest quartile (Q4) had significantly increased antioxidant levels (SOD and GPx) and decreased oxidant levels (MDA) and genetic damage (MN frequency and 8-OH-dG) than those with an FV pattern in the lowest quartile (Q1).

Conclusion: Compared to control subjects, COWs had increased oxidative stress and genetic damage. A FV dietary pattern may reverse oxidative stress and genetic damage in COWs.

语种英语
所属项目编号11ZR1401500 ; 20100071120059
资助者Shanghai Natural Science Foundation ; Doctoral Fund of Ministry of Education of China ; Shanghai Natural Science Foundation ; Doctoral Fund of Ministry of Education of China
WOS记录号WOS:000354234900001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60079
专题北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Taizhou City Ctr Dis Control & Prevent, Taizhou City 318000, Zhejiang, Peoples R China
3.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 20032, Peoples R China
推荐引用方式
GB/T 7714
Xie, Zheng,Lin, Haijiang,Fang, Renfei,et al. Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study[J]. ENVIRONMENTAL HEALTH,2015,14.
APA Xie, Zheng,Lin, Haijiang,Fang, Renfei,Shen, Weiwei,Li, Shuguang,&Chen, Bo.(2015).Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study.ENVIRONMENTAL HEALTH,14.
MLA Xie, Zheng,et al."Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study".ENVIRONMENTAL HEALTH 14(2015).
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