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学科主题: 公共卫生
题名:
Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study
作者: Xie, Zheng1; Lin, Haijiang2; Fang, Renfei1; Shen, Weiwei2; Li, Shuguang3; Chen, Bo3
关键词: Coke oven workers ; 1-hydroxypyrene (1-OHP) ; Oxidative stress ; Genetic damage ; Fruit-vegetable dietary pattern
刊名: ENVIRONMENTAL HEALTH
发表日期: 2015-05-06
DOI: 10.1186/s12940-015-0028-5
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ; MICRONUCLEUS CYTOME ASSAY ; DNA-DAMAGE ; POLYMORPHISMS ; EMISSIONS ; EXPOSURE ; BLOOD ; RISK ; FOOD ; AIR
英文摘要:

Background: Coke oven workers (COWs) are exposed to high level of genotoxic chemicals that induce oxidative stress and genetic damage. The dietary intake of certain types of foods may reverse these effects.

Methods: We conducted a cross-sectional study with 51 topside COWs, 79 other COWs, and 67 controls, to assess the effects of dietary patterns on oxidative stress and genetic damage.

Results: Compared to the controls, both topside and other COWs had significantly higher urinary 1-hydroxypyrene levels, serum oxidant levels [malondialdehyde, (MDA)], and genetic damage [micronucleus (MN) frequency & 8-oxo-2′-deoxyguanosine (8-OH-dG)], but lower antioxidant levels [superoxide dismutase (SOD) and glutathione peroxidase, (GPx)]. The fruit-vegetable (FV) dietary pattern was positively correlated with serum SOD levels and negative correlated with serum MDA, MN frequency, and urinary 8-OH-dG. COWs with an FV patter in the highest quartile (Q4) had significantly increased antioxidant levels (SOD and GPx) and decreased oxidant levels (MDA) and genetic damage (MN frequency and 8-OH-dG) than those with an FV pattern in the lowest quartile (Q1).

Conclusion: Compared to control subjects, COWs had increased oxidative stress and genetic damage. A FV dietary pattern may reverse oxidative stress and genetic damage in COWs.

语种: 英语
所属项目编号: 11ZR1401500 ; 20100071120059
项目资助者: Shanghai Natural Science Foundation ; Doctoral Fund of Ministry of Education of China
WOS记录号: WOS:000354234900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60079
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Taizhou City Ctr Dis Control & Prevent, Taizhou City 318000, Zhejiang, Peoples R China
3.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 20032, Peoples R China

Recommended Citation:
Xie, Zheng,Lin, Haijiang,Fang, Renfei,et al. Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study[J]. ENVIRONMENTAL HEALTH,2015,14.
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