|BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects|
|Liu, Lu1,2; Sun, Li1,2; Li, Ze-Hua1,2; Li, Hai-Mei1,2; Wei, Li-Ping3; Wang, Yu-Feng1,2; Qian, Qiu-Jin1,2|
|关键词||Attention-deficit/hyperactivity Disorder (Adhd) Baiap2 Hemispheric Asymmetry Subtype|
|刊名||BEHAVIORAL AND BRAIN FUNCTIONS|
|WOS标题词||Science & Technology|
|类目[WOS]||Behavioral Sciences ; Neurosciences|
|研究领域[WOS]||Behavioral Sciences ; Neurosciences & Neurology|
|关键词[WOS]||ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DEFICIT-HYPERACTIVITY-DISORDER ; RECEPTOR GENE ; CEREBRAL ASYMMETRY ; MOLECULAR-GENETICS ; CANDIDATE GENES ; MENTAL-HEALTH ; CHILDREN ; POLYMORPHISMS ; ADOLESCENTS|
Background: Attention-deficit/hyperactivity disorder (ADHD) is a common chronic neurodevelopmental disorder with a high heritability. Much evidence of hemisphere asymmetry has been found for ADHD probands from behavioral level, electrophysiological level and brain morphology. One previous research has reported possible association between BAIAP2, which is asymmetrically expressed in the two cerebral hemispheres, with ADHD in European population. The present study aimed to investigate the association between BAIAP2 and ADHD in Chinese Han subjects.
Methods: A total of 1,397 ADHD trios comprised of one ADHD proband and their parents were included for family-based association tests. Independent 569 ADHD cases and 957 normal controls were included for case-control studies. Diagnosis was performed according to the DSM-IV criteria. Nine single nucleotide polymorphisms (SNPs) of BAIAP2 were chosen and performed genotyping for both family-based and case-control association studies.
Results: Transmission disequilibrium tests (TDTs) for family-based association studies showed significant association between the CA haplotype comprised by rs3934492 and rs9901648 with predominantly inattentive type (ADHD-I). For case-control study, chi-square tests provided evidence for the contribution of SNP rs4969239, rs3934492 and rs4969385 to ADHD and its two clinical subtypes, ADHD-I and ADHD-C. However, only the associations for ADHD and ADHD-I retained significant after corrections for multiplicity or logistic regression analyses adjusting the potential confounding effect of gender and age.
Conclusions: These above results indicated the possible involvement of BAIAP2 in the etiology of ADHD, especially ADHD-I.
|项目编号||81071109 ; 81301171 ; 2014CB846104 ; NCET-11-0013|
|资助机构||National Natural Science Foundation of China ; National Basic Research Program of China ; Program for New Century Excellent Talents in University|
|作者单位||1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China|
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Coll Life Sci, Natl Lab Prot Engn & Plant Genet Engn, Ctr Bioinformat, Beijing 100871, Peoples R China
|Liu, Lu,Sun, Li,Li, Ze-Hua,et al. BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2013,9.|
|APA||Liu, Lu.,Sun, Li.,Li, Ze-Hua.,Li, Hai-Mei.,Wei, Li-Ping.,...&Qian, Qiu-Jin.(2013).BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects.BEHAVIORAL AND BRAIN FUNCTIONS,9.|
|MLA||Liu, Lu,et al."BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects".BEHAVIORAL AND BRAIN FUNCTIONS 9(2013).|