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Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes
Yu, Jie1; Han, Jiang-Li1; He, Li-Yun1; Feng, Xin-Heng1; Li, Wei-Hong1; Mao, Jie-Ming1; Gao, Wei1; Wang, Guang2
关键词Coronary flow velocity reserve Low-density lipoprotein cholesterol Endothelial function Diabetes mellitus High-density lipoprotein cholesterol
刊名JOURNAL OF GERIATRIC CARDIOLOGY
2013
DOI10.3969/j.issn.1671-5411.2013.02.007
10期:2页:159-164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]DEPENDENT VASORELAXATION ; NONINVASIVE ASSESSMENT ; MICROVASCULAR FUNCTION ; ENDOTHELIAL FUNCTION ; LDL CHOLESTEROL ; HDL CHOLESTEROL ; ECHOCARDIOGRAPHY ; VASODILATION ; DYSFUNCTION ; STENOSIS
英文摘要

Objectives To evaluate the association of coronary artery endothelial function and plasma levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in patients with Type 2 Diabetes Mellitus (DM). Methods We investigated 90 participants from our institution between October 2007 to March 2010: non-DM (n = 60) and DM (n = 30). As an indicator of coronary endothelial dysfunction, we used non-invasive Doppler echocardiography to quantify coronary flow velocity reserve (CFVR) in the distal part of the left descending artery after rest and after intravenous adenosine administration. Results Plasma level of LDL-C was significantly higher in patients with DM than in non-DM (3.21 +/- 0.64 vs. 2.86 +/- 0.72 mmo/L, P < 0.05), but HDL-C level did not differ between the groups (1.01 +/- 0.17 vs. 1.05 +/- 0.19 mmo/L). Furthermore, the CFVR value was lower in DM patients than non-diabetics (2.45 +/- 0.62 vs. 2.98 +/- 0.68, P < 0.001). Plasma levels of LDL-C were negatively correlated with CFVR in all subjects (r = -0.35, P < 0.001; 95% confidence interval (CI): -0.52 - -0.15) and in the non-DM (r = -0.29, P < 0.05; 95% CI: -0.51 - -0.05), with an even stronger negative correlation in the DM group (r = -0.42, P < 0.05; 95% CI: -0.68 - -0.06). Age (beta = -0.019, s = 0.007, s beta = -0.435, 95% CI: -0.033 - -0.005, P = 0.008), LDL-C (beta = -0.217, s = 0.105, s beta = -0.282, 95% CI: -0.428 - -0.005, P = 0.045) remained independently correlated with CFVR in the DM group. However, we found no correlation between HDL-C level and CFVR in any group. Conclusions Diabetes may contribute to coronary artery disease (CAD) by inducing dysfunction of the coronary artery endothelium. Increased LDL-C level may adversely impair coronary endothelial function in DM. HDL-C may lose its endothelial-protective effects, in part as a result of pathological conditions, especially under abnormal glucose metabolism.

语种英语
WOS记录号WOS:000321197300008
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60083
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China
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GB/T 7714
Yu, Jie,Han, Jiang-Li,He, Li-Yun,et al. Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2013,10(2):159-164.
APA Yu, Jie.,Han, Jiang-Li.,He, Li-Yun.,Feng, Xin-Heng.,Li, Wei-Hong.,...&Wang, Guang.(2013).Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes.JOURNAL OF GERIATRIC CARDIOLOGY,10(2),159-164.
MLA Yu, Jie,et al."Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes".JOURNAL OF GERIATRIC CARDIOLOGY 10.2(2013):159-164.
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