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学科主题: 临床医学
题名:
Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes
作者: Yu, Jie1; Han, Jiang-Li1; He, Li-Yun1; Feng, Xin-Heng1; Li, Wei-Hong1; Mao, Jie-Ming1; Gao, Wei1; Wang, Guang2
关键词: Coronary flow velocity reserve ; Low-density lipoprotein cholesterol ; Endothelial function ; Diabetes mellitus ; High-density lipoprotein cholesterol
刊名: JOURNAL OF GERIATRIC CARDIOLOGY
发表日期: 2013
DOI: 10.3969/j.issn.1671-5411.2013.02.007
卷: 10, 期:2, 页:159-164
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]: Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]: DEPENDENT VASORELAXATION ; NONINVASIVE ASSESSMENT ; MICROVASCULAR FUNCTION ; ENDOTHELIAL FUNCTION ; LDL CHOLESTEROL ; HDL CHOLESTEROL ; ECHOCARDIOGRAPHY ; VASODILATION ; DYSFUNCTION ; STENOSIS
英文摘要:

Objectives To evaluate the association of coronary artery endothelial function and plasma levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in patients with Type 2 Diabetes Mellitus (DM). Methods We investigated 90 participants from our institution between October 2007 to March 2010: non-DM (n = 60) and DM (n = 30). As an indicator of coronary endothelial dysfunction, we used non-invasive Doppler echocardiography to quantify coronary flow velocity reserve (CFVR) in the distal part of the left descending artery after rest and after intravenous adenosine administration. Results Plasma level of LDL-C was significantly higher in patients with DM than in non-DM (3.21 +/- 0.64 vs. 2.86 +/- 0.72 mmo/L, P < 0.05), but HDL-C level did not differ between the groups (1.01 +/- 0.17 vs. 1.05 +/- 0.19 mmo/L). Furthermore, the CFVR value was lower in DM patients than non-diabetics (2.45 +/- 0.62 vs. 2.98 +/- 0.68, P < 0.001). Plasma levels of LDL-C were negatively correlated with CFVR in all subjects (r = -0.35, P < 0.001; 95% confidence interval (CI): -0.52 - -0.15) and in the non-DM (r = -0.29, P < 0.05; 95% CI: -0.51 - -0.05), with an even stronger negative correlation in the DM group (r = -0.42, P < 0.05; 95% CI: -0.68 - -0.06). Age (beta = -0.019, s = 0.007, s beta = -0.435, 95% CI: -0.033 - -0.005, P = 0.008), LDL-C (beta = -0.217, s = 0.105, s beta = -0.282, 95% CI: -0.428 - -0.005, P = 0.045) remained independently correlated with CFVR in the DM group. However, we found no correlation between HDL-C level and CFVR in any group. Conclusions Diabetes may contribute to coronary artery disease (CAD) by inducing dysfunction of the coronary artery endothelium. Increased LDL-C level may adversely impair coronary endothelial function in DM. HDL-C may lose its endothelial-protective effects, in part as a result of pathological conditions, especially under abnormal glucose metabolism.

语种: 英语
WOS记录号: WOS:000321197300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60083
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China

Recommended Citation:
Yu, Jie,Han, Jiang-Li,He, Li-Yun,et al. Low density lipoprotein cholesterol level inversely correlated with coronary flow velocity reserve in patients with Type 2 diabetes[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2013,10(2):159-164.
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