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An efficient synthesis of (R)- and (S)-baclofen via desymmetrization
Ji, Lei1; Ma, Yuheng1; Li, Jin2; Zhang, Liangren1; Zhang, Lihe1
刊名TETRAHEDRON LETTERS
2009-11-11
DOI10.1016/j.tetlet.2009.08.079
50期:45页:6166-6168
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者Shenogen Pharma Group ; Shenogen Pharma Group
研究领域[WOS]Chemistry
关键词[WOS]ENANTIOSELECTIVE SYNTHESIS ; CYCLIC ANHYDRIDES ; ASYMMETRIC-SYNTHESIS ; KINETIC RESOLUTION ; CINCHONA ALKALOIDS ; MICHAEL ADDITION ; ACID ANHYDRIDES ; (R)-(-)-BACLOFEN ; BACLOFEN ; DERIVATIVES
英文摘要

A short and highly enantioselective synthesis of both enantiomers of GABA agonist baclofen in four steps with total yields of 32.8% [for(S)-isomer] and 35.1% [for (R)-isomer] is reported. The key step involved desymmetrization of cyclic anhydride with modified cinchona alkaloids. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
资助者Shenogen Pharma Group ; Shenogen Pharma Group
WOS记录号WOS:000270765700016
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60084
Collection北京大学药学院
作者单位1.Shenogen Pharm Grp, Beijing 100085, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ji, Lei,Ma, Yuheng,Li, Jin,et al. An efficient synthesis of (R)- and (S)-baclofen via desymmetrization[J]. TETRAHEDRON LETTERS,2009,50(45):6166-6168.
APA Ji, Lei,Ma, Yuheng,Li, Jin,Zhang, Liangren,&Zhang, Lihe.(2009).An efficient synthesis of (R)- and (S)-baclofen via desymmetrization.TETRAHEDRON LETTERS,50(45),6166-6168.
MLA Ji, Lei,et al."An efficient synthesis of (R)- and (S)-baclofen via desymmetrization".TETRAHEDRON LETTERS 50.45(2009):6166-6168.
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