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学科主题: 药学
题名:
An efficient synthesis of (R)- and (S)-baclofen via desymmetrization
作者: Ji, Lei1; Ma, Yuheng1; Li, Jin2; Zhang, Liangren1; Zhang, Lihe1
刊名: TETRAHEDRON LETTERS
发表日期: 2009-11-11
DOI: 10.1016/j.tetlet.2009.08.079
卷: 50, 期:45, 页:6166-6168
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ENANTIOSELECTIVE SYNTHESIS ; CYCLIC ANHYDRIDES ; ASYMMETRIC-SYNTHESIS ; KINETIC RESOLUTION ; CINCHONA ALKALOIDS ; MICHAEL ADDITION ; ACID ANHYDRIDES ; (R)-(-)-BACLOFEN ; BACLOFEN ; DERIVATIVES
英文摘要:

A short and highly enantioselective synthesis of both enantiomers of GABA agonist baclofen in four steps with total yields of 32.8% [for(S)-isomer] and 35.1% [for (R)-isomer] is reported. The key step involved desymmetrization of cyclic anhydride with modified cinchona alkaloids. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: Shenogen Pharma Group
WOS记录号: WOS:000270765700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60084
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shenogen Pharm Grp, Beijing 100085, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Ji, Lei,Ma, Yuheng,Li, Jin,et al. An efficient synthesis of (R)- and (S)-baclofen via desymmetrization[J]. TETRAHEDRON LETTERS,2009,50(45):6166-6168.
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