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Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats
Zhang, XN; Tang, LH; Gonga, JH; Xu, XY; Zhang, Q
关键词albendazole nanoparticles targeting index tissue distribution bioavailability pharmacokinetics
刊名LETTERS IN DRUG DESIGN & DISCOVERY
2006-05-01
3期:4页:275-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PLASMA-PROTEIN ADSORPTION ; ECHINOCOCCOSIS ; ALBUMIN ; CHINA
英文摘要

Two loaded nanoparticles. albendazole polybutylcyanoacrylate nanoparticles (ABZ-PBCA-NP) and albendazole polyvinylpyrrolidone. Polybutylcyanoacrylate nanoparticles (ABZ-PVP-PBCA-NP) were prepared by the emulsification-polymerization method. Tissue distribution and tissue targeting of ABZ-PBCA-NP in mice was studied. The drug-load mechanism of ABZ-PBCA-NP was studied by the equal-temperature absorption principle. The drug loaded in nanoparticle was coincident with the Langmuir adsorption equation. The dialyzed dynamic of albendazole from four formulations, ABZ-PBCA-NP. PVP-ABZ-PBCA-NP. ABZ suspension (SABZ) and ABZ liquid (1,ABZ),. was investigated in vitro. ABZ-PBCA-NP and PVP-ABZ-PBCA-NP were suitable for the Higuchi and bi-exponent function respectively. The absorptive capability of the drug was enhanced when 4% PVP was added into the nanoparticle, and its release time was increased. The tissue distribution of albendazole in different drug vehicles was studied by isotope labeling experiment. Targeting index of albendazole in liver and spleen in mice was estimated at 11.4 and 3.9 after ig H-3-ABZ-PBCA-NP. The bioavailability of albendazole nanoparticle and suspension was 76.0% and 36.9%, respectively. The results have shown that the nanoparticle vehicles increase the albendazole bioavailability.

语种英语
WOS记录号WOS:000238247500008
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60088
专题北京大学药学院_药剂学系
作者单位1.Soochow Univ, Coll Pharm, Dept Pharmaceut, Suzhou 215123, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, XN,Tang, LH,Gonga, JH,et al. Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2006,3(4):275-280.
APA Zhang, XN,Tang, LH,Gonga, JH,Xu, XY,&Zhang, Q.(2006).Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats.LETTERS IN DRUG DESIGN & DISCOVERY,3(4),275-280.
MLA Zhang, XN,et al."Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats".LETTERS IN DRUG DESIGN & DISCOVERY 3.4(2006):275-280.
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