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学科主题: 药学
题名:
Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats
作者: Zhang, XN; Tang, LH; Gonga, JH; Xu, XY; Zhang, Q
关键词: albendazole nanoparticles ; targeting index ; tissue distribution ; bioavailability ; pharmacokinetics
刊名: LETTERS IN DRUG DESIGN & DISCOVERY
发表日期: 2006-05-01
卷: 3, 期:4, 页:275-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PLASMA-PROTEIN ADSORPTION ; ECHINOCOCCOSIS ; ALBUMIN ; CHINA
英文摘要:

Two loaded nanoparticles. albendazole polybutylcyanoacrylate nanoparticles (ABZ-PBCA-NP) and albendazole polyvinylpyrrolidone. Polybutylcyanoacrylate nanoparticles (ABZ-PVP-PBCA-NP) were prepared by the emulsification-polymerization method. Tissue distribution and tissue targeting of ABZ-PBCA-NP in mice was studied. The drug-load mechanism of ABZ-PBCA-NP was studied by the equal-temperature absorption principle. The drug loaded in nanoparticle was coincident with the Langmuir adsorption equation. The dialyzed dynamic of albendazole from four formulations, ABZ-PBCA-NP. PVP-ABZ-PBCA-NP. ABZ suspension (SABZ) and ABZ liquid (1,ABZ),. was investigated in vitro. ABZ-PBCA-NP and PVP-ABZ-PBCA-NP were suitable for the Higuchi and bi-exponent function respectively. The absorptive capability of the drug was enhanced when 4% PVP was added into the nanoparticle, and its release time was increased. The tissue distribution of albendazole in different drug vehicles was studied by isotope labeling experiment. Targeting index of albendazole in liver and spleen in mice was estimated at 11.4 and 3.9 after ig H-3-ABZ-PBCA-NP. The bioavailability of albendazole nanoparticle and suspension was 76.0% and 36.9%, respectively. The results have shown that the nanoparticle vehicles increase the albendazole bioavailability.

语种: 英语
WOS记录号: WOS:000238247500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60088
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Soochow Univ, Coll Pharm, Dept Pharmaceut, Suzhou 215123, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, XN,Tang, LH,Gonga, JH,et al. Alternative albendazole polybutylcyanoacrylate nanoparticles preparation, pharmaceutical properties and tissue distribution in rats[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2006,3(4):275-280.
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