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Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure
Wang, B.1; Xiao, B. B.1; Shang, C. G.1; Wang, K.2; Na, R. S.1; Nu, X. X.1; Liao, Q.1
刊名EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2014-10-01
DOI10.1007/s10096-014-2128-5
33期:10页:1749-1756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]ORAL METRONIDAZOLE ; INTRAVAGINAL METRONIDAZOLE ; SEX WORKERS ; WOMEN ; PREVALENCE ; RECURRENCE ; IDENTIFICATION ; ASSOCIATIONS ; RESISTANCE ; SYMPTOMS
英文摘要

Bacterial vaginosis frequently persists, even after treatment. The role of some strains of bacteria associated with bacterial vaginosis treatment failure remains poorly defined. The aim of our study was to define the risk of bacterial vaginosis treatment failure, including pre-treatment detection of specific vaginal bacteria. Bacterial vaginosis is present when the Nugent score is >= 7 and the modified Amsel criteria is positive. Women with bacterial vaginosis were treated with intravaginal metronidazole gel nightly for 5 nights. The 454 pyrosequencing method was used to detect bacteria in vaginal fluid. By univariate analysis, a history of bacterial vaginosis, intrauterine device use and the presence of Facklamia, Corynebacterium and Veillonella were significantly associated with bacterial vaginosis treatment failure. Lactobacillus crispatus, Lactobacillus pentosus and Megasphaera were significantly associated with curing bacterial vaginosis. After logistic regression analysis and detection of these bacteria for test-of-cure, we found that women who had a history of bacterial vaginosis had a higher incidence of bacterial vaginosis treatment failure, whereas women with L. crispatus had a lower incidence of treatment failure. Post-treatment sexual activity was not associated with the treatment effect. Our data suggested that treatment failure may be not caused by drug resistance. Rather, it has a closer relationship with the failed restoration of lactobacilli.

语种英语
WOS记录号WOS:000343139000010
项目编号81200411 ; 81170535
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60092
专题北京大学第一临床医学院
作者单位1.Xingtai Maternal & Child Hlth Hosp, Xingtai, Peoples R China
2.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
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GB/T 7714
Wang, B.,Xiao, B. B.,Shang, C. G.,et al. Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2014,33(10):1749-1756.
APA Wang, B..,Xiao, B. B..,Shang, C. G..,Wang, K..,Na, R. S..,...&Liao, Q..(2014).Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,33(10),1749-1756.
MLA Wang, B.,et al."Molecular analysis of the relationship between specific vaginal bacteria and bacterial vaginosis metronidazole therapy failure".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 33.10(2014):1749-1756.
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