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学科主题: 公共卫生
题名:
Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats
作者: Zeng Jing1,2; Yan LaiLai1,2; Ouyang Li1,2; Wu Jing1; Wang JingYu1,2
关键词: lead fingerprint ; isotopic ratio ; blood ; hair ; tissues ; organs ; rats
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2012-03-01
DOI: 10.1007/s11434-011-4953-6
卷: 57, 期:7, 页:744-749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ICP-MS ; RATIOS ; CAIS
英文摘要:

Lead isotopic ratios of biosamples such as blood, hair and teeth are used as "fingerprints" to trace and identify sources of lead pollution in the environment. However, the reliability of this technique has not been confirmed. In previous studies, we investigated the differences in lead isotopic ratios between blood, hair, and organs from the same human body. To explore the relationship between isotopic ratios in environmental lead and biosamples, and to investigate the influence of exposure dose, rats were exposed to 0, 30, 60, and 120 mg/kg body weight of lead acetate every day for 4 weeks by intragastric administration. Lead isotopic ratios of blood, hair, liver, kidney and femur in rats, as well as that of the test substance lead acetate, were measured using inductively coupled plasma mass spectrometry. There were significant differences (P < 0.05) in lead isotopic fingerprints between blood, hair, and tissues. Lead fingerprints of blood were influenced by lead exposure dose, while those of other tissues and organs were generally not. Its reliability and availability indicated that blood, but not hair, was thus a suitable biomarker for environmental lead exposure. The results of this study provide the scientific rationale for the use of lead isotopic ratios for the identification of human lead pollution sources.

语种: 英语
所属项目编号: 30972434 ; 2009ZX09502-027-4
项目资助者: National Natural Science Foundation of China ; National Science and Technology Major Project
WOS记录号: WOS:000300771200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60093
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China

Recommended Citation:
Zeng Jing,Yan LaiLai,Ouyang Li,et al. Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats[J]. CHINESE SCIENCE BULLETIN,2012,57(7):744-749.
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