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Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats
Zeng Jing1,2; Yan LaiLai1,2; Ouyang Li1,2; Wu Jing1; Wang JingYu1,2
关键词lead fingerprint isotopic ratio blood hair tissues organs rats
刊名CHINESE SCIENCE BULLETIN
2012-03-01
DOI10.1007/s11434-011-4953-6
57期:7页:744-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ICP-MS ; RATIOS ; CAIS
英文摘要

Lead isotopic ratios of biosamples such as blood, hair and teeth are used as "fingerprints" to trace and identify sources of lead pollution in the environment. However, the reliability of this technique has not been confirmed. In previous studies, we investigated the differences in lead isotopic ratios between blood, hair, and organs from the same human body. To explore the relationship between isotopic ratios in environmental lead and biosamples, and to investigate the influence of exposure dose, rats were exposed to 0, 30, 60, and 120 mg/kg body weight of lead acetate every day for 4 weeks by intragastric administration. Lead isotopic ratios of blood, hair, liver, kidney and femur in rats, as well as that of the test substance lead acetate, were measured using inductively coupled plasma mass spectrometry. There were significant differences (P < 0.05) in lead isotopic fingerprints between blood, hair, and tissues. Lead fingerprints of blood were influenced by lead exposure dose, while those of other tissues and organs were generally not. Its reliability and availability indicated that blood, but not hair, was thus a suitable biomarker for environmental lead exposure. The results of this study provide the scientific rationale for the use of lead isotopic ratios for the identification of human lead pollution sources.

语种英语
WOS记录号WOS:000300771200007
项目编号30972434 ; 2009ZX09502-027-4
资助机构National Natural Science Foundation of China ; National Science and Technology Major Project
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60093
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学第三临床医学院_介入血管外科
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China
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Zeng Jing,Yan LaiLai,Ouyang Li,et al. Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats[J]. CHINESE SCIENCE BULLETIN,2012,57(7):744-749.
APA Zeng Jing,Yan LaiLai,Ouyang Li,Wu Jing,&Wang JingYu.(2012).Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats.CHINESE SCIENCE BULLETIN,57(7),744-749.
MLA Zeng Jing,et al."Differences in lead isotopic fingerprints between blood, hair and organs in lead-poisoned rats".CHINESE SCIENCE BULLETIN 57.7(2012):744-749.
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