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学科主题: 临床医学
题名:
Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity
作者: Xu, Peng-Cheng1; Zhang, Jun-Jun1,2; Chen, Min1; Lv, Ji-Cheng1; Liu, Gang1; Zou, Wan-Zhong1; Zhang, Hong1; Zhao, Ming-Hui1
关键词: IgA nephropathy ; KIM-1 ; tubulointerstitial lesions
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2011-10-01
DOI: 10.1093/ndt/gfr023
卷: 26, 期:10, 页:3229-3236
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: NATURAL-HISTORY ; CLINICAL-FEATURES ; PROTEIN-OVERLOAD ; RENAL-DISEASE ; BIOMARKER ; KIM-1 ; EXPRESSION ; BIOPSIES ; TISSUE ; CHINA
英文摘要:

Background. The pathological characteristics of IgA nephropathy (IgAN) are highly variable. Urinary kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubule injury. The aim of the study is to investigate the value of KIM-1 as a biomarker for assessing the renal injury in IgAN.

Methods. The levels of urinary KIM-1 in 202 patients with IgAN, 46 patients with other renal diseases as disease controls and 60 healthy blood donors as normal controls were measured. Correlations with clinical and histopathological features of patients with IgAN were evaluated.

Results. The levels of urinary KIM-1 were significantly higher in patients with IgAN than in normal controls (P < 0.001) and in patients with non-IgAN (P = 0.011). Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance. The more severe the tubulointerstitial injury was, the higher the levels of urinary KIM-1. Patients with severe mesangial proliferation, crescents formation or endocapillary proliferation had higher levels of urinary KIM-1 than those without. The levels of tubular KIM-1 expression in immunohistochemistry closely correlated with the levels of urinary KIM-1 (r = 0.553, P = 0.032). Renal survival was significantly worse in patients with elevated urinary KIM-1 (P = 0.020).

Conclusion. Urinary KIM-1 may be a useful biomarker to evaluate kidney injury in IgAN.

语种: 英语
所属项目编号: 30570852 ; 30972733 ; 2004230003 ; 2007BAI04B10
项目资助者: National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; Peking University ; National Key Technology R &amp ; D Program, People&prime ; s Republic of China
WOS记录号: WOS:000296349200029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60094
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Div Renal, Dept Med,Inst Nephrol,Key Lab Renal Dis,Minist Hl, Beijing 100871, Peoples R China
2.Zhengzhou Univ, Dept Nephrol, Affiliated Hosp 1, Zhengzhou, Peoples R China

Recommended Citation:
Xu, Peng-Cheng,Zhang, Jun-Jun,Chen, Min,et al. Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(10):3229-3236.
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