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Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity
Xu, Peng-Cheng1; Zhang, Jun-Jun1,2; Chen, Min1; Lv, Ji-Cheng1; Liu, Gang1; Zou, Wan-Zhong1; Zhang, Hong1; Zhao, Ming-Hui1
关键词IgA nephropathy KIM-1 tubulointerstitial lesions
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2011-10-01
DOI10.1093/ndt/gfr023
26期:10页:3229-3236
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]NATURAL-HISTORY ; CLINICAL-FEATURES ; PROTEIN-OVERLOAD ; RENAL-DISEASE ; BIOMARKER ; KIM-1 ; EXPRESSION ; BIOPSIES ; TISSUE ; CHINA
英文摘要

Background. The pathological characteristics of IgA nephropathy (IgAN) are highly variable. Urinary kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubule injury. The aim of the study is to investigate the value of KIM-1 as a biomarker for assessing the renal injury in IgAN.

Methods. The levels of urinary KIM-1 in 202 patients with IgAN, 46 patients with other renal diseases as disease controls and 60 healthy blood donors as normal controls were measured. Correlations with clinical and histopathological features of patients with IgAN were evaluated.

Results. The levels of urinary KIM-1 were significantly higher in patients with IgAN than in normal controls (P < 0.001) and in patients with non-IgAN (P = 0.011). Urinary levels of KIM-1 in IgAN positively correlated with levels of serum creatinine and proteinuria and negatively with creatinine clearance. The more severe the tubulointerstitial injury was, the higher the levels of urinary KIM-1. Patients with severe mesangial proliferation, crescents formation or endocapillary proliferation had higher levels of urinary KIM-1 than those without. The levels of tubular KIM-1 expression in immunohistochemistry closely correlated with the levels of urinary KIM-1 (r = 0.553, P = 0.032). Renal survival was significantly worse in patients with elevated urinary KIM-1 (P = 0.020).

Conclusion. Urinary KIM-1 may be a useful biomarker to evaluate kidney injury in IgAN.

语种英语
WOS记录号WOS:000296349200029
项目编号30570852 ; 30972733 ; 2004230003 ; 2007BAI04B10
资助机构National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; Peking University ; National Key Technology R &amp ; D Program, People&prime ; s Republic of China
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60094
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学第一临床医学院_病理科
作者单位1.Peking Univ, Peking Univ Hosp 1, Div Renal, Dept Med,Inst Nephrol,Key Lab Renal Dis,Minist Hl, Beijing 100871, Peoples R China
2.Zhengzhou Univ, Dept Nephrol, Affiliated Hosp 1, Zhengzhou, Peoples R China
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GB/T 7714
Xu, Peng-Cheng,Zhang, Jun-Jun,Chen, Min,et al. Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(10):3229-3236.
APA Xu, Peng-Cheng.,Zhang, Jun-Jun.,Chen, Min.,Lv, Ji-Cheng.,Liu, Gang.,...&Zhao, Ming-Hui.(2011).Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity.NEPHROLOGY DIALYSIS TRANSPLANTATION,26(10),3229-3236.
MLA Xu, Peng-Cheng,et al."Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity".NEPHROLOGY DIALYSIS TRANSPLANTATION 26.10(2011):3229-3236.
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