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学科主题: 基础医学
题名:
A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats
作者: Zuo, Yan-Fang; Wang, Jin-Yan; Chen, Ji-Huan; Qiao, Zhi-Mei; Han, Ji-Sheng; Cui, Cai-Lian; Luo, Fei
关键词: morphine ; opioid addiction ; conditioned place preference ; drug-seeking ; electroencephalogram
刊名: BRAIN RESEARCH
发表日期: 2007-03-09
DOI: 10.1016/j.brainres.2006.11.099
卷: 1136, 期:1, 页:88-101
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FREELY MOVING RATS ; ETHANOL-INDUCED INTOXICATION ; DELTA-OPIOID INTERACTIONS ; ALCOHOL-RELATED STIMULI ; EEG SPECTRAL POWER ; ATTENTIONAL BIAS ; CUE-REACTIVITY ; NEURONAL RESPONSES ; OPIATE DEPENDENCE ; COGNITIVE BIASES
英文摘要:

Previous studies demonstrated that drug cues could elicit drug-like or withdrawal-like effect, both subjectively and physiologically. However, few studies have compared the central activities induced by a drug-related environment and the drug itself. The aim of this study was to observe and compare electroencephalographic (EEG) changes induced by acute morphine administration and by the morphine-related environment. EEG activities were recorded via twelve skull electrodes scattered on the left and right cortex in conscious, freely moving rats, either after acute morphine administration or after successful training of conditioned place preference. Acute administration of morphine (0.1, 0.5, 1, 5, 10,20 mg/kg, i. p.) produced an increase in absolute EEG power in the delta, theta, alphal, alpha2, betal, and beta2 bands, as well as a decrease in the gamma band. Topographic mapping revealed a maximal increase in the lateral leads in the theta band and a maximal change in the centrofrontal region in the remaining bands. After place conditioning training, the morphine-related environment induced a diffuse decrease in absolute power in the delta, theta, alphal, alpha2, betal, and beta2 bands, which was opposite to the changes induced by acute morphine administration. In addition, the changes in relative power induced by the two situations also diverged. These results indicate that the central mechanisms underlying the motivation of morphine-induced place preference may be somehow different from those underlying the reward effects produced by acute morphine administration. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000244882500009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60096
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 10083, Peoples R China

Recommended Citation:
Zuo, Yan-Fang,Wang, Jin-Yan,Chen, Ji-Huan,et al. A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats[J]. BRAIN RESEARCH,2007,1136(1):88-101.
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