IR@PKUHSC  > 北京大学药学院
学科主题药学
3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells
Zhou, Junjun1,2; Sun, Yi1,2; Zhao, Xin1,2; Deng, Zheng1,2; Pu, Xiaoping1,2
关键词3-O-Demethylswertipunicoside 1-Methyl-4-phenylpyridinium Oxidative stress Apoptosis Parkinson&prime s disease PC12 cells
刊名BRAIN RESEARCH
2013-05-01
DOI10.1016/j.brainres.2013.02.049
1508页:53-62
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Innovative Drug Research Fund of Founder Group &amp ; Peking University Health Science Center ; National Natural Science Foundation of China ; Innovative Drug Research Fund of Founder Group &amp ; Peking University Health Science Center ; National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PARKINSONS-DISEASE ; HUMAN NEUROBLASTOMA ; SWERTIA-PUNICEA ; REACTIVE OXYGEN ; SH-SY5Y CELLS ; DEATH ; MECHANISMS ; BCL-2 ; TOXICITY ; MITOCHONDRIA
英文摘要

The 3-O-demethylswertipunicoside (3-ODS) is extracted from Swertia punicea. Recent study from our laboratory has demonstrated that the 3-ODS protects against oxidative toxicity and apoptosis in PC12 cells (Zhang, S.P., Du, X.G., Pu, X.P., 2010. Biol. Pharm. Bull. 33, 1529-1533). The aim of our study is to further investigate the neuroprotective mechanisms of 3-ODS in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in PC12 cells. The results indicated that pre-treatment with 3-ODS significantly increased the cell viability compared with MPP+ treatment. It also alleviated the oxidative stress by increasing superoxide dismutase (SOD) activity and decreasing malondialdehyde (MDA) level and reactive oxygen specise (ROS) production. Moreover, 3-ODS also attenuated MPP+-induced apoptosis by inhibiting Bax and Bcl-2 expressions, activating caspase-9, caspase-3, poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, apoptosis-inducing factor (AIF) translocation and alpha-synuclein expression. These results suggest that 3-ODS might has applications as a complementary medicine for the treatment of Parkinson′s disease (PD) or other neurodegenerative diseases. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
所属项目编号Founder 201004 ; 30973889
资助者Innovative Drug Research Fund of Founder Group &amp ; Peking University Health Science Center ; National Natural Science Foundation of China ; Innovative Drug Research Fund of Founder Group &amp ; Peking University Health Science Center ; National Natural Science Foundation of China
WOS记录号WOS:000318751200006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60097
专题北京大学药学院
作者单位1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Junjun,Sun, Yi,Zhao, Xin,et al. 3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells[J]. BRAIN RESEARCH,2013,1508:53-62.
APA Zhou, Junjun,Sun, Yi,Zhao, Xin,Deng, Zheng,&Pu, Xiaoping.(2013).3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells.BRAIN RESEARCH,1508,53-62.
MLA Zhou, Junjun,et al."3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells".BRAIN RESEARCH 1508(2013):53-62.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Junjun]的文章
[Sun, Yi]的文章
[Zhao, Xin]的文章
百度学术
百度学术中相似的文章
[Zhou, Junjun]的文章
[Sun, Yi]的文章
[Zhao, Xin]的文章
必应学术
必应学术中相似的文章
[Zhou, Junjun]的文章
[Sun, Yi]的文章
[Zhao, Xin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。