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学科主题: 药学
题名:
3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells
作者: Zhou, Junjun1,2; Sun, Yi1,2; Zhao, Xin1,2; Deng, Zheng1,2; Pu, Xiaoping1,2
关键词: 3-O-Demethylswertipunicoside ; 1-Methyl-4-phenylpyridinium ; Oxidative stress ; Apoptosis ; Parkinson&prime ; s disease ; PC12 cells
刊名: BRAIN RESEARCH
发表日期: 2013-05-01
DOI: 10.1016/j.brainres.2013.02.049
卷: 1508, 页:53-62
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PARKINSONS-DISEASE ; HUMAN NEUROBLASTOMA ; SWERTIA-PUNICEA ; REACTIVE OXYGEN ; SH-SY5Y CELLS ; DEATH ; MECHANISMS ; BCL-2 ; TOXICITY ; MITOCHONDRIA
英文摘要:

The 3-O-demethylswertipunicoside (3-ODS) is extracted from Swertia punicea. Recent study from our laboratory has demonstrated that the 3-ODS protects against oxidative toxicity and apoptosis in PC12 cells (Zhang, S.P., Du, X.G., Pu, X.P., 2010. Biol. Pharm. Bull. 33, 1529-1533). The aim of our study is to further investigate the neuroprotective mechanisms of 3-ODS in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in PC12 cells. The results indicated that pre-treatment with 3-ODS significantly increased the cell viability compared with MPP+ treatment. It also alleviated the oxidative stress by increasing superoxide dismutase (SOD) activity and decreasing malondialdehyde (MDA) level and reactive oxygen specise (ROS) production. Moreover, 3-ODS also attenuated MPP+-induced apoptosis by inhibiting Bax and Bcl-2 expressions, activating caspase-9, caspase-3, poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, apoptosis-inducing factor (AIF) translocation and alpha-synuclein expression. These results suggest that 3-ODS might has applications as a complementary medicine for the treatment of Parkinson′s disease (PD) or other neurodegenerative diseases. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: Founder 201004 ; 30973889
项目资助者: Innovative Drug Research Fund of Founder Group &amp ; Peking University Health Science Center ; National Natural Science Foundation of China
WOS记录号: WOS:000318751200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60097
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Junjun,Sun, Yi,Zhao, Xin,et al. 3-O-demethylswertipunicoside inhibits MPP+-induced oxidative stress and apoptosis in PC12 cells[J]. BRAIN RESEARCH,2013,1508:53-62.
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