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学科主题: 临床医学
题名:
Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis
作者: Chang, Chun1; Guo, Zhi-guo2; He, Bei1; Yao, Wan-zhen1
关键词: mild persistent asthma ; Chinese patients ; serum metabolites ; metabolomics ; succinate ; inosine ; GC-MS
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2015-11-01
DOI: 10.1038/aps.2015.102
卷: 36, 期:11, 页:1356-1366
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: EXHALED BREATH CONDENSATE ; RESPIRATORY-DISEASES ; GAS-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; CHILDHOOD ASTHMA ; URINE SAMPLES ; BIOMARKERS ; PATHOGENESIS ; PROFILES ; PATHWAYS
英文摘要:

Aim: To character the specific metabolomics profiles in the sera of Chinese patients with mild persistent asthma and to explore potential metabolic biomarkers.

Methods: Seventeen Chinese patients with mild persistent asthma and age-and sex-matched healthy controls were enrolled. Serum samples were collected, and serum metabolites were analyzed using GC-MS coupled with a series of multivariate statistical analyses.

Results: Clear intergroup separations existed between the asthmatic patients and control subjects. A list of differential metabolites and several top altered metabolic pathways were identified. The levels of succinate (an intermediate in tricarboxylic acid cycle) and inosine were highly upregulated in the asthmatic patients, suggesting a greater effort to breathe during exacerbation and hypoxic stress due to asthma. Other differential metabolites, such as 3,4-dihydroxybenzoic acid and phenylalanine, were also identified. Furthermore, the differential metabolites possessed higher values of area under the ROC curve (AUC), suggesting an excellent clinical ability for the prediction of asthma.

Conclusion: Metabolic activity is significantly altered in the sera of Chinese patients with mild persistent asthma. The data might be helpful for identifying novel biomarkers and therapeutic targets for asthma.

语种: 英语
所属项目编号: 07010440052 ; 81400017
项目资助者: Special Fund of the Chinese Medical Association for the Scientific Research of Chronic Respiratory Tract Diseases ; National Natural Science Foundation of China-Youth Fund Project
WOS记录号: WOS:000365048700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60099
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Emergency Med, Beijing 100191, Peoples R China

Recommended Citation:
Chang, Chun,Guo, Zhi-guo,He, Bei,et al. Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis[J]. ACTA PHARMACOLOGICA SINICA,2015,36(11):1356-1366.
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