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Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis
Chang, Chun1; Guo, Zhi-guo2; He, Bei1; Yao, Wan-zhen1
关键词Mild Persistent Asthma Chinese Patients Serum Metabolites Metabolomics Succinate Inosine Gc-ms
刊名ACTA PHARMACOLOGICA SINICA
2015-11-01
DOI10.1038/aps.2015.102
36期:11页:1356-1366
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]EXHALED BREATH CONDENSATE ; RESPIRATORY-DISEASES ; GAS-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; CHILDHOOD ASTHMA ; URINE SAMPLES ; BIOMARKERS ; PATHOGENESIS ; PROFILES ; PATHWAYS
英文摘要

Aim: To character the specific metabolomics profiles in the sera of Chinese patients with mild persistent asthma and to explore potential metabolic biomarkers.

Methods: Seventeen Chinese patients with mild persistent asthma and age-and sex-matched healthy controls were enrolled. Serum samples were collected, and serum metabolites were analyzed using GC-MS coupled with a series of multivariate statistical analyses.

Results: Clear intergroup separations existed between the asthmatic patients and control subjects. A list of differential metabolites and several top altered metabolic pathways were identified. The levels of succinate (an intermediate in tricarboxylic acid cycle) and inosine were highly upregulated in the asthmatic patients, suggesting a greater effort to breathe during exacerbation and hypoxic stress due to asthma. Other differential metabolites, such as 3,4-dihydroxybenzoic acid and phenylalanine, were also identified. Furthermore, the differential metabolites possessed higher values of area under the ROC curve (AUC), suggesting an excellent clinical ability for the prediction of asthma.

Conclusion: Metabolic activity is significantly altered in the sera of Chinese patients with mild persistent asthma. The data might be helpful for identifying novel biomarkers and therapeutic targets for asthma.

语种英语
WOS记录号WOS:000365048700009
项目编号07010440052 ; 81400017
资助机构Special Fund of the Chinese Medical Association for the Scientific Research of Chronic Respiratory Tract Diseases ; National Natural Science Foundation of China-Youth Fund Project
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60099
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Emergency Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chang, Chun,Guo, Zhi-guo,He, Bei,et al. Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis[J]. ACTA PHARMACOLOGICA SINICA,2015,36(11):1356-1366.
APA Chang, Chun,Guo, Zhi-guo,He, Bei,&Yao, Wan-zhen.(2015).Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis.ACTA PHARMACOLOGICA SINICA,36(11),1356-1366.
MLA Chang, Chun,et al."Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis".ACTA PHARMACOLOGICA SINICA 36.11(2015):1356-1366.
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