IR@PKUHSC  > 北京大学药学院
学科主题药学
Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinediones as Anti-Angiogenesis Agents
Huang, Conghai; Meng, Xiangbao; Cui, Jingrong; Li, Zhongjun
关键词quinazolinediones anti-angiogenesis triphosgene
刊名MOLECULES
2009-07-01
DOI10.3390/molecules14072447
14期:7页:2447-2457
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Science Foundation of China ; National Science Foundation of China
研究领域[WOS]Chemistry
关键词[WOS]AMINOPEPTIDASE INHIBITORS ; 2,4-QUINAZOLINEDIONES ; DERIVATIVES ; GLUCOSAMINE
英文摘要

A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3( 2′-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.

语种英语
所属项目编号30672525 ; 20732001
资助者National Science Foundation of China ; National Science Foundation of China
WOS记录号WOS:000268318300011
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60100
Collection北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Huang, Conghai,Meng, Xiangbao,Cui, Jingrong,et al. Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinediones as Anti-Angiogenesis Agents[J]. MOLECULES,2009,14(7):2447-2457.
APA Huang, Conghai,Meng, Xiangbao,Cui, Jingrong,&Li, Zhongjun.(2009).Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinediones as Anti-Angiogenesis Agents.MOLECULES,14(7),2447-2457.
MLA Huang, Conghai,et al."Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinediones as Anti-Angiogenesis Agents".MOLECULES 14.7(2009):2447-2457.
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