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学科主题: 公共卫生
题名:
Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
作者: Yang, Sheng-Tao1; Wang, Xiang2; Jia, Guang2; Gu, Yiqun3; Wang, Tiancheng4; Nie, Haiyu1; Ge, Cuicui5,6; Wang, Haifang1; Liu, Yuanfang1
关键词: Carbon nanotubes ; Intravenous administration ; Accumulation ; Toxicity ; Oxidative stress
刊名: TOXICOLOGY LETTERS
发表日期: 2008-10-01
DOI: 10.1016/j.toxlet.2008.07.020
卷: 181, 期:3, 页:182-189
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: IN-VIVO ; PULMONARY TOXICITY ; BIODISTRIBUTION ; CYTOTOXICITY ; BIOAVAILABILITY ; NANOPARTICLES ; CIRCULATION ; DEPENDENCE ; TOXICOLOGY ; CELLS
英文摘要:

The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 10490180 ; 2006CB705604
项目资助者: China Natural Science Foundation ; China Ministry of Science and Technology
WOS记录号: WOS:000260646100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60103
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Matern Hosp Haidian Dist, Beijing 100080, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
4.Peking Univ, Third Hosp, Dept Clin Lab, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat & Nanosafe, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China

Recommended Citation:
Yang, Sheng-Tao,Wang, Xiang,Jia, Guang,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):182-189.
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