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Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
Yang, Sheng-Tao1; Wang, Xiang2; Jia, Guang2; Gu, Yiqun3; Wang, Tiancheng4; Nie, Haiyu1; Ge, Cuicui5,6; Wang, Haifang1; Liu, Yuanfang1
关键词Carbon nanotubes Intravenous administration Accumulation Toxicity Oxidative stress
刊名TOXICOLOGY LETTERS
2008-10-01
DOI10.1016/j.toxlet.2008.07.020
181期:3页:182-189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
研究领域[WOS]Toxicology
关键词[WOS]IN-VIVO ; PULMONARY TOXICITY ; BIODISTRIBUTION ; CYTOTOXICITY ; BIOAVAILABILITY ; NANOPARTICLES ; CIRCULATION ; DEPENDENCE ; TOXICOLOGY ; CELLS
英文摘要

The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号10490180 ; 2006CB705604
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
WOS记录号WOS:000260646100007
Citation statistics
Cited Times:218[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60103
Collection北京大学公共卫生学院
作者单位1.Matern Hosp Haidian Dist, Beijing 100080, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
4.Peking Univ, Third Hosp, Dept Clin Lab, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat & Nanosafe, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Sheng-Tao,Wang, Xiang,Jia, Guang,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):182-189.
APA Yang, Sheng-Tao.,Wang, Xiang.,Jia, Guang.,Gu, Yiqun.,Wang, Tiancheng.,...&Liu, Yuanfang.(2008).Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.TOXICOLOGY LETTERS,181(3),182-189.
MLA Yang, Sheng-Tao,et al."Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice".TOXICOLOGY LETTERS 181.3(2008):182-189.
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