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学科主题: 临床医学
题名:
Intraocular expression of thymosin beta 4 in proliferative diabetic retinopathy
作者: Wang, Jia-Yan1; Lu, Qiang1; Tao, Yong1,2; Jiang, Yan-Rong1; Jonas, Jost B.2
关键词: diabetes mellitus ; diabetic retinopathy ; neovascularization ; thymosin beta 4
刊名: ACTA OPHTHALMOLOGICA
发表日期: 2011-08-01
DOI: 10.1111/j.1755-3768.2011.02114.x
卷: 89, 期:5, 页:E396-E403
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; CELLS ; ERYTHROPOIETIN ; FLUID ; ANGIOGENESIS ; TISSUES ; PROTEIN ; EDEMA
英文摘要:

Purpose: To examine an association between thymosin beta 4 as potentially angio-proliferative factor and proliferative diabetic retinopathy.

Methods: The clinical study part included 62 patients with proliferative diabetic retinopathy (PDR) (study group) and 24 patients with non-diabetic pre-retinal membranes (control group). All patients underwent pars plana vitrectomy. We examined the thymosin beta 4 concentration in vitreous and plasma; and the expression of thymosin beta 4, glial fibrillary acidic protein (GFAP) and CD31 (PECAM-1 or Platelet Endothelial Cell Adhesion Molecule) and the levels of thymosin beta 4 mRNA and vascular endothelial growth factor (VEGF) mRNA in the excised membranes. The experimental study part consisted of 24 Sprague-Dawley rats with streptozotocin-induced diabetes mellitus and 24 age-matched control animals without diabetes. We determined the mRNA concentrations of thymosin beta 4, VEGF and GFAP in the rat retinas.

Results: In the clinical study part, the vitreal and plasma thymosin beta 4 concentrations were significantly higher in the study group than control group (p = 0.04 and p = 0.01, respectively), and were significantly (p = 0.028) correlated with each other. Co-expression of thymosin beta 4 and CD31 was observed in the diabetic fibrovascular membranes. Thymosin beta 4 mRNA and VEGF mRNA levels were significantly (p < 0.01) higher in diabetic membranes than in non-diabetic membranes. In the experimental study part, the diabetic retinas showed co-localization of thymosin beta 4 and GFAP. The mRNA levels of thymosin b4, VEGF and GFAP were significantly (p < 0.01) higher in diabetic rats than in control animals.

Conclusions: Thymosin beta 4 was produced in intraocular fibrovascular membranes of patients with PDR and in rats with experimental diabetes mellitus. Thymosin beta 4 may play a role in diabetic retinal neovascularization.

语种: 英语
WOS记录号: WOS:000292742800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60106
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China
2.Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany

Recommended Citation:
Wang, Jia-Yan,Lu, Qiang,Tao, Yong,et al. Intraocular expression of thymosin beta 4 in proliferative diabetic retinopathy[J]. ACTA OPHTHALMOLOGICA,2011,89(5):E396-E403.
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