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学科主题: 临床医学
题名:
Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han
作者: Cai, Yue-ming1; Wang, Jing2; Wang, Qing-wen1,2; Long, Xia3; Wang, Wei-guang1; Zhang, Lu1; Zeng, Hui-ping1; Wu, Zhi-cheng3
关键词: Single nucleotide ; Polymorphism ; Rheumatoid arthritis ; OPG
刊名: IMMUNOLOGY LETTERS
发表日期: 2015-06-01
DOI: 10.1016/j.imlet.2014.07.011
卷: 165, 期:2, 页:102-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MINERAL DENSITY ; KOREAN POSTMENOPAUSAL WOMEN ; OSTEOPROTEGERIN GENE ; RECEPTOR ACTIVATOR ; OSTEOPOROSIS ; DISEASE ; RANKL ; RATIO
英文摘要:

Aim: To investigate the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735), 245T/G (rs3134069) with susceptibility to rheumatoid arthritis (RA) in Chinese Han population. Objective: To study the correlation between the disease of rheumatoid arthritis (RA) in Chinese Han group and the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735) and 245T/G (rs3134069). Approaches: 205 RA patients and 171 healthy control subjects were participated into this study. Genotype analysis was conducted by polymerase chain reaction-based restriction fragment length polymorphism and was subsequently confirmed by DNA sequencing. Odd ration (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele. Consequences: OPG gene polymorphisms 163A/G, 245T/G conformed to the Hardy-Weinberg equilibrium. The statistical differences in genotype of AA, AG, GG at 163A/G locus were founded in RA and controls. The G allele was associated with an increased risk of RA, with OR 1.219 (95% CI: 1.066-2.339). According to the observation, there are no significant differences between the RA and control groups with respect to genotype and allele frequencies of OPG gene 245T/G (chi(2) = 0.734, 0.518, p > 0.05). Conclusion: The OPG gene 163A/G SNP may be associated with the susceptibility of RA, G allele may be the risk factor for the development of RA. (C) 2014 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000356195300006
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60108
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, ShenZhen Hosp, Dept Rheumatol & Immunol, Shenzhen, Peoples R China
2.Anhui Med Univ, Shenzhen Hosp, Peking Univ, Clin Coll, Hefei, Anhui, Peoples R China
3.Peking Univ, ShenZhen Hosp, Dept Ctr Lab, Shenzhen, Peoples R China

Recommended Citation:
Cai, Yue-ming,Wang, Jing,Wang, Qing-wen,et al. Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han[J]. IMMUNOLOGY LETTERS,2015,165(2):102-106.
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