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Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han
Cai, Yue-ming1; Wang, Jing2; Wang, Qing-wen1,2; Long, Xia3; Wang, Wei-guang1; Zhang, Lu1; Zeng, Hui-ping1; Wu, Zhi-cheng3
关键词Single nucleotide Polymorphism Rheumatoid arthritis OPG
刊名IMMUNOLOGY LETTERS
2015-06-01
DOI10.1016/j.imlet.2014.07.011
165期:2页:102-106
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]BONE-MINERAL DENSITY ; KOREAN POSTMENOPAUSAL WOMEN ; OSTEOPROTEGERIN GENE ; RECEPTOR ACTIVATOR ; OSTEOPOROSIS ; DISEASE ; RANKL ; RATIO
英文摘要

Aim: To investigate the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735), 245T/G (rs3134069) with susceptibility to rheumatoid arthritis (RA) in Chinese Han population. Objective: To study the correlation between the disease of rheumatoid arthritis (RA) in Chinese Han group and the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735) and 245T/G (rs3134069). Approaches: 205 RA patients and 171 healthy control subjects were participated into this study. Genotype analysis was conducted by polymerase chain reaction-based restriction fragment length polymorphism and was subsequently confirmed by DNA sequencing. Odd ration (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele. Consequences: OPG gene polymorphisms 163A/G, 245T/G conformed to the Hardy-Weinberg equilibrium. The statistical differences in genotype of AA, AG, GG at 163A/G locus were founded in RA and controls. The G allele was associated with an increased risk of RA, with OR 1.219 (95% CI: 1.066-2.339). According to the observation, there are no significant differences between the RA and control groups with respect to genotype and allele frequencies of OPG gene 245T/G (chi(2) = 0.734, 0.518, p > 0.05). Conclusion: The OPG gene 163A/G SNP may be associated with the susceptibility of RA, G allele may be the risk factor for the development of RA. (C) 2014 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000356195300006
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60108
专题北京大学深圳医院
作者单位1.Peking Univ, ShenZhen Hosp, Dept Rheumatol & Immunol, Shenzhen, Peoples R China
2.Anhui Med Univ, Shenzhen Hosp, Peking Univ, Clin Coll, Hefei, Anhui, Peoples R China
3.Peking Univ, ShenZhen Hosp, Dept Ctr Lab, Shenzhen, Peoples R China
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Cai, Yue-ming,Wang, Jing,Wang, Qing-wen,et al. Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han[J]. IMMUNOLOGY LETTERS,2015,165(2):102-106.
APA Cai, Yue-ming.,Wang, Jing.,Wang, Qing-wen.,Long, Xia.,Wang, Wei-guang.,...&Wu, Zhi-cheng.(2015).Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han.IMMUNOLOGY LETTERS,165(2),102-106.
MLA Cai, Yue-ming,et al."Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han".IMMUNOLOGY LETTERS 165.2(2015):102-106.
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