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Analysis of eight free progestogens in eggs by matrix solid-phase dispersion extraction and very high pressure liquid chromatography with tandem mass spectrometry
Yang, Yi1; Shao, Bing1,4; Zhang, Jing1; Wu, Yongning2; Ying, Jie3
关键词progestogens matrix solid-phase dispersion LC-ESI-MS/MS
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2008-07-15
DOI10.1016/j.jchromb.2008.06.021
870期:2页:241-246
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ANABOLIC-STEROIDS ; HUMAN PLASMA ; MEAT ; HORMONES ; RESIDUES ; ESTROGENS ; ANDROGENS ; TISSUES ; SAMPLES ; FOOD
英文摘要

A rapid method to identify and quantify unconjugated progestogens in eggs is presented. Samples were prepared based on matrix solid-phase dispersion (MSPD) using C18 as dispersant, followed by a cleanup step with graphitized carbon black (GCB) solid-phase extraction (SPE) cartridges. The analytes were separated by very high pressure LC on a BEH C18 column for a period of 5 min, Electrospray ionization tandem mass spectrometry (ESI-MS/MS) was operated in the positive time-scheduled multi-reaction monitoring mode. Recovery studies were performed at two fortification levels. Average recoveries of the target compounds varied from 83.8% to 111.2% and relative standard deviations ranged from 10.5% to 23.7%. The limits of detection (LODs) and limits of quantitation (LOQs) were in the range of 0.2-2.0 mu g kg(-1) and 0.6-5.0 mu g kg(-1), respectively. Investigation of real samples indicated that the range of progesterone in eggs was 9.9-40.0 mu g kg(-1). (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000258388600016
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60110
专题北京大学公共卫生学院
作者单位1.Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China
2.China Ctr Dis Control & Prevent, Natl Inst Nutr & Food Safety, Beijing 100085, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100083, Peoples R China
4.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100089, Peoples R China
推荐引用方式
GB/T 7714
Yang, Yi,Shao, Bing,Zhang, Jing,et al. Analysis of eight free progestogens in eggs by matrix solid-phase dispersion extraction and very high pressure liquid chromatography with tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,870(2):241-246.
APA Yang, Yi,Shao, Bing,Zhang, Jing,Wu, Yongning,&Ying, Jie.(2008).Analysis of eight free progestogens in eggs by matrix solid-phase dispersion extraction and very high pressure liquid chromatography with tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,870(2),241-246.
MLA Yang, Yi,et al."Analysis of eight free progestogens in eggs by matrix solid-phase dispersion extraction and very high pressure liquid chromatography with tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 870.2(2008):241-246.
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