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学科主题: 基础医学
题名:
Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery
作者: Du, Libo1; Suo, Siqingaowa1; Luo, Dan2,3; Jia, Hongying1; Sha, Yinlin2,3; Liu, Yang1
关键词: Graphene ; Methotrexate ; Drug delivery ; Cytotoxicity ; Anticancer drugs
刊名: JOURNAL OF NANOPARTICLE RESEARCH
发表日期: 2013-06-01
DOI: 10.1007/s11051-013-1708-0
卷: 15, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: CONTROLLED-RELEASE ; CARBON NANOTUBES ; DOXORUBICIN ; DRUGS ; NANOCARRIER
英文摘要:

In this study, we presented a simple approach to prepare hydroxyethylated graphene oxide (HE-GO) with high water solubility and physiological stability. The successful synthesis of HE-GO was confirmed by UV-Vis spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The loading of anticancer drug methotrexate (MTX) onto this nanocarrier (MTX/HE-GO) was investigated. The results of in vitro drug release experiment showed that the rate of MTX release from MTX/HE-GO was pH dependent. Moreover, cell viability assay demonstrated that HE-GO loaded with MTX exhibits higher anticancer activity against human lung adenocarcinoma epithelial cell line than non-vehicle MTX.

语种: 英语
所属项目编号: 91227122 ; 90813021
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000319516400038
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60123
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China

Recommended Citation:
Du, Libo,Suo, Siqingaowa,Luo, Dan,et al. Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery[J]. JOURNAL OF NANOPARTICLE RESEARCH,2013,15(6).
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