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学科主题: 临床医学
题名:
Early lymphocyte recovery predicts superior overall survival after unmanipulated haploidentical blood and marrow transplant for myelodysplastic syndrome and acute myeloid leukemia evolving from myelodysplastic syndrome
作者: Chang, Ying-Jun1,2; Zhao, Xiang-Yu1,2; Xu, Lan-Ping1,2; Liu, Dai-Hong1,2; Liu, Kai-Yan1,2; Chen, Yu-Hong1,2; Wang, Yu1,2; Zhang, Xiao-Hui1,2; Zhao, Xiao-Su1,2; Han, Wei1,2; Chen, Huan1,2; Wang, Feng-Rong1,2; Lv, Meng1,2; Huang, Xiao-Jun1,2,3
关键词: Lymphocyte recovery ; unmanipulated haploidentical blood and marrow transplant ; absolute lymphocyte count ; immune recovery ; transplant outcomes ; myelodysplastic syndrome
刊名: LEUKEMIA & LYMPHOMA
发表日期: 2013-12-01
DOI: 10.3109/10428194.2013.783912
卷: 54, 期:12, 页:2671-2677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; IMMUNE RECONSTITUTION ; HEMATOLOGIC MALIGNANCIES ; CLINICAL IMPACT ; CHRONIC GRAFT ; HOST-DISEASE ; CORD BLOOD ; T-CELLS ; HLA ; OUTCOMES
英文摘要:

We investigated whether early lymphocyte recovery, after unmanipulated, haploidentical, blood and marrow transplant (HBMT), affected clinical outcomes in 78 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia evolving from MDS. Lymphocyte recovery was based on the absolute lymphocyte count on day 30 (ALC-30). Patients with high ALC-30 (>= 300 cells/mL) had lower relapse rates (13.8% vs. 35.5%, p = 0.049) and lower incidence of bacterial infections (3.4% vs. 25.8%, p = 0.015) than those with low ALC-30 values. Multivariate analysis showed that a high ALC-30 was associated with improved overall survival (OS, hazard ratio [HR]: 0.099, 95% confidence interval [CI]: 0.029-0.337; p < 0.0001), improved leukemia-free survival (HR: 0.245, 95% CI: 0.112-0.539; p < 0.0001), lower relapse rate (HR: 0.096, 95% CI: 0.011-0.827; p = 0.033) and lower transplant-related mortality (TRM, HR: 0.073, 95% CI: 0.016-0.324; p = 0.001). Combinations of three mismatches in the human leukocyte antigen loci were associated with a higher TRM (HR: 5.026, 95% CI: 1.392-18.173; p = 0.014). Our results suggest that the ALC-30 can predict a favorable OS after unmanipulated HBMT.

语种: 英语
所属项目编号: 30725038
项目资助者: Clinical Subjects&prime ; Key Project of the Ministry of Health ; National Natural Science Foundation of China
WOS记录号: WOS:000326633700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60125
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing Key Lab HSCT, Beijing 100044, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Zhao, Xiang-Yu,Xu, Lan-Ping,et al. Early lymphocyte recovery predicts superior overall survival after unmanipulated haploidentical blood and marrow transplant for myelodysplastic syndrome and acute myeloid leukemia evolving from myelodysplastic syndrome[J]. LEUKEMIA &amp; LYMPHOMA,2013,54(12):2671-2677.
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