IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray
Wang, Ying1,2; Yang, Xiaoping3; Liu, Wentao4; Zhang, Feng5; Cai, Qing3; Deng, Xuliang1,2
关键词microparticles electrospray controlled release drug delivery
刊名JOURNAL OF MICROENCAPSULATION
2013
DOI10.3109/02652048.2012.752537
30期:5页:490-497
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
资助者National Basic Research Program of China ; International Science and Technology Cooperation Program ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Program of China ; International Science and Technology Cooperation Program ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]CONTROLLED DRUG-DELIVERY ; ELECTROHYDRODYNAMIC ATOMIZATION ; BIODEGRADABLE MICROSPHERES ; ANTIGEN DELIVERY ; ENCAPSULATION ; PARTICLES ; MICROENCAPSULATION ; INTERFACE ; SYSTEMS ; PROFILE
英文摘要

Biodegradable poly (lactic-co-glycolic acid) (PLGA) microparticles are an effective way to achieve sustained drug release. In this study, we investigated a sustained release model of PLGA microparticles with incorporated protein via either emulsion or coaxial electrospray techniques. PLGA (75:25) was used as the carrier, and bovine serum albumin as a model protein. Coaxial electrospray resulted in a type of core-shell structure with mean diameters of 2.41 +/- 0.60 mu m and a centralised protein distribution within the core. Emulsion electrospray formed bigger microparticles with mean diameters of 22.75 +/- 8.05 mu m and a heterogeneous protein distribution throughout the microparticles. The coaxial electrospray microparticles presented a much slighter burst release than the emulsion electrospray microparticles. Loading efficiency was significantly higher (p < 0.05) in the coaxial group than emulsion group. This indicated that both emulsion and coaxial electrospray could produce protein-loaded microparticles with sustained release behaviour, but the former revealed a superior approach for drug delivery.

语种英语
所属项目编号2012CB933900 ; 2010DFA51500 ; 51073016 ; 81171000 ; NCET-11-0556
资助者National Basic Research Program of China ; International Science and Technology Cooperation Program ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Program of China ; International Science and Technology Cooperation Program ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号WOS:000320951800009
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60126
Collection北京大学口腔医学院
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
3.Beijing Univ Chem Technol, Coll Mat Sci & Engn, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
4.Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China
5.Beijing Armed Police Force, Hosp 2, Oral Clin, Beijing 100037, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ying,Yang, Xiaoping,Liu, Wentao,et al. Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray[J]. JOURNAL OF MICROENCAPSULATION,2013,30(5):490-497.
APA Wang, Ying,Yang, Xiaoping,Liu, Wentao,Zhang, Feng,Cai, Qing,&Deng, Xuliang.(2013).Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray.JOURNAL OF MICROENCAPSULATION,30(5),490-497.
MLA Wang, Ying,et al."Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray".JOURNAL OF MICROENCAPSULATION 30.5(2013):490-497.
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