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IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室  > 期刊论文
学科主题: 临床医学
题名:
Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma
作者: Jin, Ke-min1; Lu, Min4; Liu, Fang-fang2; Gu, Jin3; Du, Xiao-juan5,6; Xing, Bao-cai1
关键词: Hepatocellular carcinoma (HCC) ; Carcinogenesis ; Prognosis ; Cortactin
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2010-06-01
DOI: 10.1007/s11670-010-0112-x
卷: 22, 期:2, 页:112-118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; EMS1 GENE ; V-SRC ; MOTILITY ; INVASION ; PHOSPHORYLATION ; AMPLIFICATION ; METASTASIS ; EXPRESSION
英文摘要:

To investigate cortactin expression in hepatocellular carcinoma (HCC) and explore its significance in the prognosis of HCC patients.

Immunohistochemistry was performed for paraffin samples of 119 pairs of HCC tissues (HCCs) and paratumorous liver tissues (PTLTs) to evaluate cortactin expression. The cortactin expression difference in HCCs and PTLTs were analyzed by the McNemar′s test. The relationship of cortactin expressions in HCCs and clinicopathologic factors was analyzed with Mann-Whitney U test. The Kaplan-Meier method and log-rank test were employed to compare the overall survival between Cortactin negative expression group, weak expression group and strong expression group. Expression of cortactin was further determined in 19 pairs of fresh HCCs and PTLTs specimens with Western blotting.

Cortactin expression rate was significantly higher in HCCs (53/119, 44.5%) than that in PTLTs (2/119, 1.7%) (P < 0.001). The upregulated cortactin expression in HCCs was significantly correlated to absence of capsule formation (P=0.012), vascular invasion (P=0.037) and high Edmondson-Steiner grade (P=0.020), and predicted shorter overall survival. Western blotting demonstrated that cortactin expression was upregulated in 9 out of 19 HCCs (47.4%) compared to corresponding PTLTs.

Cortactin expression is upregulated in HCC and is related to shorter overall survival of patients, suggesting that cortactin might play roles in the metastasis of HCC and predict a poor prognosis of HCC patients.

语种: 英语
所属项目编号: 2006AA02A308 ; H030230280410 ; 2008ZX 10002-016
项目资助者: National "863" High Technology Research and Development Program of China ; Beijing Municipal Key Project ; National Key Technologies R&amp ; D Program of China
WOS记录号: WOS:000279026100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60130
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Hepat Biliary & Pancreat Surg Unit 1, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Dept Genet, Sch Oncol, Beijing 100142, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg Unit 2, Sch Oncol, Beijing 100142, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Ke-min,Lu, Min,Liu, Fang-fang,et al. Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(2):112-118.
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