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学科主题临床医学
Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma
Jin, Ke-min1; Lu, Min4; Liu, Fang-fang2; Gu, Jin3; Du, Xiao-juan5,6; Xing, Bao-cai1
关键词Hepatocellular carcinoma (HCC) Carcinogenesis Prognosis Cortactin
刊名CHINESE JOURNAL OF CANCER RESEARCH
2010-06-01
DOI10.1007/s11670-010-0112-x
22期:2页:112-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National "863" High Technology Research and Development Program of China ; Beijing Municipal Key Project ; National Key Technologies R&amp ; D Program of China ; National "863" High Technology Research and Development Program of China ; Beijing Municipal Key Project ; National Key Technologies R&amp ; D Program of China
研究领域[WOS]Oncology
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; EMS1 GENE ; V-SRC ; MOTILITY ; INVASION ; PHOSPHORYLATION ; AMPLIFICATION ; METASTASIS ; EXPRESSION
英文摘要

To investigate cortactin expression in hepatocellular carcinoma (HCC) and explore its significance in the prognosis of HCC patients.

Immunohistochemistry was performed for paraffin samples of 119 pairs of HCC tissues (HCCs) and paratumorous liver tissues (PTLTs) to evaluate cortactin expression. The cortactin expression difference in HCCs and PTLTs were analyzed by the McNemar′s test. The relationship of cortactin expressions in HCCs and clinicopathologic factors was analyzed with Mann-Whitney U test. The Kaplan-Meier method and log-rank test were employed to compare the overall survival between Cortactin negative expression group, weak expression group and strong expression group. Expression of cortactin was further determined in 19 pairs of fresh HCCs and PTLTs specimens with Western blotting.

Cortactin expression rate was significantly higher in HCCs (53/119, 44.5%) than that in PTLTs (2/119, 1.7%) (P < 0.001). The upregulated cortactin expression in HCCs was significantly correlated to absence of capsule formation (P=0.012), vascular invasion (P=0.037) and high Edmondson-Steiner grade (P=0.020), and predicted shorter overall survival. Western blotting demonstrated that cortactin expression was upregulated in 9 out of 19 HCCs (47.4%) compared to corresponding PTLTs.

Cortactin expression is upregulated in HCC and is related to shorter overall survival of patients, suggesting that cortactin might play roles in the metastasis of HCC and predict a poor prognosis of HCC patients.

语种英语
所属项目编号2006AA02A308 ; H030230280410 ; 2008ZX 10002-016
资助者National "863" High Technology Research and Development Program of China ; Beijing Municipal Key Project ; National Key Technologies R&amp ; D Program of China ; National "863" High Technology Research and Development Program of China ; Beijing Municipal Key Project ; National Key Technologies R&amp ; D Program of China
WOS记录号WOS:000279026100005
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60130
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Hepat Biliary & Pancreat Surg Unit 1, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Dept Genet, Sch Oncol, Beijing 100142, Peoples R China
3.Peking Univ, Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg Unit 2, Sch Oncol, Beijing 100142, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jin, Ke-min,Lu, Min,Liu, Fang-fang,et al. Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(2):112-118.
APA Jin, Ke-min,Lu, Min,Liu, Fang-fang,Gu, Jin,Du, Xiao-juan,&Xing, Bao-cai.(2010).Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,22(2),112-118.
MLA Jin, Ke-min,et al."Cortactin overexpression correlates with poor prognosis in hepatocellular carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 22.2(2010):112-118.
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