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学科主题: 药物依赖
题名:
Role of amygdala in drug memory
作者: Luo, Yi-Xiao; Xue, Yan-Xue; Shen, Hao-Wei; Lu, Lin
关键词: Addiction ; Relapse ; Amygdala ; Drug memory
刊名: NEUROBIOLOGY OF LEARNING AND MEMORY
发表日期: 2013-10-01
DOI: 10.1016/j.nlm.2013.06.017
卷: 105, 期:SI, 页:159-173
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Behavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Psychology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; ROSTRAL BASOLATERAL AMYGDALA ; STRESS-INDUCED REINSTATEMENT ; NUCLEUS-ACCUMBENS CORE ; C-FOS EXPRESSION ; MGLUR(2/3) AGONIST LY379268 ; OPIATE-WITHDRAWAL MEMORIES ; GAMMA-AMINOBUTYRIC-ACID ; STIMULUS-REWARD MEMORY
英文摘要:

Drug addiction is a chronic brain disorder with the hallmark of a high rate of relapse to compulsive drug seeking and drug taking even after long-term abstinence. Addiction has been considered as an aberrant memory that has been termed "addiction memory." Drug-related memory plays a critical role in the maintenance of learned addictive behaviors and emergence of relapse. Disrupting these long-lasting memories by administering amnestic agents or other manipulations during specific phases of drug memory is a promising strategy for relapse prevention. Recent studies on the processes of drug addiction and relapse have demonstrated that the amygdala is involved in associative drug addiction learning processes. In this review, we focus on preclinical studies that used conditioned place preference and self-administration models to investigate the differential roles of the amygdala in each phase of drug-related memory, including acquisition, consolidation, retrieval, reconsolidation, and extinction. These studies indicate that the amygdala plays a critical role in both cue-associative learning and the expression of cue-induced relapse to drug-seeking behavior. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 31230033 ; 81221002 ; 91132716
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000324508800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60134
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Yi-Xiao,Xue, Yan-Xue,Shen, Hao-Wei,et al. Role of amygdala in drug memory[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,105(SI):159-173.
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