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学科主题临床医学
Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation
Huang, Xiao-Jun; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Chen, Huan; Han, Wei
关键词donor lymphocyte infusion relapse haploidentical transplantation
刊名HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
2007-03-01
92期:3页:414-417
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; LEUKOCYTE INFUSIONS ; MYELOID-LEUKEMIA ; MALIGNANCIES
英文摘要

In this study, we tested the efficacy and safety of donor lymphocyte infusion (DLI) with granulocyte colony-stimulating factor (G-CSF) priming in patients who relapsed after haploidentical hematopoietic stem cell transplantation (HSCT). Twenty patients received DLI at a median of 177 days after HSCT Eight patients survived in complete remission for a median of 1118 days. The 2-year probability of leukemia-free survival was 40%. Acute graft-versus-host disease (GVHD) grade 3-4 occurred in six patients after DLI. GVHD prophylaxis reduced the incidence of acute GVHD. Our primary data showed that G-CSF-primed DLI with GVHD prophylaxis was a potentially effective therapeutic option for patients who relapsed after haploidentical HSCT.

语种英语
WOS记录号WOS:000244839500020
引用统计
被引频次:91[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60136
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Huang, Xiao-Jun,Liu, Dai-Hong,Liu, Kai-Yan,et al. Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation[J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL,2007,92(3):414-417.
APA Huang, Xiao-Jun,Liu, Dai-Hong,Liu, Kai-Yan,Xu, Lan-Ping,Chen, Huan,&Han, Wei.(2007).Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation.HAEMATOLOGICA-THE HEMATOLOGY JOURNAL,92(3),414-417.
MLA Huang, Xiao-Jun,et al."Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation".HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 92.3(2007):414-417.
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