北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement
作者: Zhao, Ningning1; Lin, Jiuxiang1; Kanzaki, Hiroyuki2; Ni, Juhua3; Chen, Zhibin4; Liang, Wei1; Liu, Yan1
刊名: AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
发表日期: 2012
DOI: 10.1016/j.ajodo.2011.06.035
卷: 141, 期:1, 页:30-40
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: HVJ ENVELOPE VECTOR ; BONE-RESORPTION ; HEMAGGLUTINATING VIRUS ; VOLUME FRACTION ; RATS ; RANKL ; TEETH ; RETENTION ; STABILITY ; ACCURACY
英文摘要:

Introduction: In orthodontic treatment, teeth can relapse after tooth movement without retention. The aim of this study was to evaluate the inhibition effects of local osteoprotegerin (OPG) gene transfer on orthodontic relapse. Methods: Eighteen male Wistar rats were divided into 3 groups. The maxillary right first molars of all animals were subjected to orthodontic force and moved mesially. Three weeks later, the force was removed, and the teeth relapsed. During the 2-week relapse period, the 3 groups of rats received local OPG gene transfer (experimental group), mock vector transfer (mock group), and no injections (control group). Tooth movement and relapse were measured by using palatal superimpositions of 3-dimensional digital models. Histomorphometric analysis was used to quantify osteoclasts, and microcomputed tomography analysis was done to quantify the alveolar bone and the tibia. Results: Relapse was significantly inhibited and the number of osteoclasts was reduced in the experimental group. On the other hand, bone mineral density and bone volume fraction of alveolar bone were significantly increased. Bone mineral density and bone volume fraction of the tibia showed no significant difference between the groups. Conclusions: Local OPG gene transfer to periodontal tissues could inhibit relapse after orthodontic tooth movement, through the inhibition of osteoclastogenesis. (Am J Orthod Dentofacial Orthop 2012;141:30-40)

语种: 英语
所属项目编号: 30801313
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000298370500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60141
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Orthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Tohoku Univ, Grad Sch Dent, Dept Oral Hlth & Dev Sci, Div Orthodont & Dentofacial Orthoped, Sendai, Miyagi 980, Japan
3.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100081, Peoples R China
4.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Zhao, Ningning,Lin, Jiuxiang,Kanzaki, Hiroyuki,et al. Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement[J]. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS,2012,141(1):30-40.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Ningning]'s Articles
[Lin, Jiuxiang]'s Articles
[Kanzaki, Hiroyuki]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Ningning]‘s Articles
[Lin, Jiuxiang]‘s Articles
[Kanzaki, Hiroyuki]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace