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学科主题: 临床医学
题名:
Ameliorative effect of ozone on cytokine production in mice injected with human rheumatoid arthritis synovial fibroblast cells
作者: Chang, JDS; Lu, HS; Chang, YF; Wang, D
关键词: decreased cytokine secretion ; ozone therapy ; rheumatoid arthritis ; synovial fibroblast cells
刊名: RHEUMATOLOGY INTERNATIONAL
发表日期: 2005-12-01
DOI: 10.1007/s00296-004-0526-1
卷: 26, 期:2, 页:142-151
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: PRIMARY-CULTURE ; BONE DESTRUCTION ; MESSENGER-RNA ; INTERLEUKIN-1 ; SYNOVIOCYTES ; INFLAMMATION ; EXPRESSION ; MEMBRANE ; PROTEIN ; MODEL
英文摘要:

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by invasion of hyperplastic synovial cells and progressive joint destruction. Ozone therapy has been proposed as an immunomodulator and cellular metabolic activator which shows long-term anti-inflammatory effects and serves to reduce further the proinflammatory factors. We purified RA synovial fibroblast cells (RA-SFc) from patients and avoided contaminating macrophages by flow cytometry, then treated them with ozone. Following the observable decreased production of proinflammatory factors TNF-alpha, IL-1 beta, and IL-6 from RA-SFc, we infused the cultured RA-SFc into joints of severe combined immunodeficiency mice. The mRNA and protein levels of the RA-SFc exposed to 3% and 5% ozone were the same. As a result, 3% and 5% ozone applied externally ameliorated the inflammatory reaction of RA without toxicity or serious side effects. Therefore, ozone injected into the knees of RA patients could become a valuable treatment, and we confirm the interactive mechanism between ozone and RA-SFc.

语种: 英语
WOS记录号: WOS:000233872100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60143
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Johnson Gen Hosp, Dept Orthopaed, Changhua, Taiwan
2.Peking Univ, Grad Sch, Inst Bone & Joint, Peoples Hosp, Beijing, Peoples R China
3.Vancouver Gen Hosp, Ozone Therapy Dept, Vancouver, BC, Canada

Recommended Citation:
Chang, JDS,Lu, HS,Chang, YF,et al. Ameliorative effect of ozone on cytokine production in mice injected with human rheumatoid arthritis synovial fibroblast cells[J]. RHEUMATOLOGY INTERNATIONAL,2005,26(2):142-151.
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