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学科主题: 药物依赖
题名:
Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
作者: Liu, YL; Liang, JH; Yan, LD; Su, RB; Wu, CF; Gong, ZH
关键词: l-tetrahydropalmatine ; oxycodone ; locomotor sensitization
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2005-05-01
DOI: 10.1111/j.1745-7254.2005.00101.x
卷: 26, 期:5, 页:533-538
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: DOPAMINE-RECEPTOR ANTAGONISTS ; CALCIUM-CHANNEL INHIBITORS ; BEHAVIORAL SENSITIZATION ; MORPHINE ; EXPRESSION ; ADDICTION ; COCAINE ; RATS ; BLOCKERS ; HEROIN
英文摘要:

Aim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.

语种: 英语
WOS记录号: WOS:000229103500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60148
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Liu, YL,Liang, JH,Yan, LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538.
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