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Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
Liu, YL; Liang, JH; Yan, LD; Su, RB; Wu, CF; Gong, ZH
关键词l-tetrahydropalmatine oxycodone locomotor sensitization
刊名ACTA PHARMACOLOGICA SINICA
2005-05-01
DOI10.1111/j.1745-7254.2005.00101.x
26期:5页:533-538
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]DOPAMINE-RECEPTOR ANTAGONISTS ; CALCIUM-CHANNEL INHIBITORS ; BEHAVIORAL SENSITIZATION ; MORPHINE ; EXPRESSION ; ADDICTION ; COCAINE ; RATS ; BLOCKERS ; HEROIN
英文摘要

Aim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.

语种英语
WOS记录号WOS:000229103500004
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60148
专题中国药物依赖性研究所
作者单位1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, YL,Liang, JH,Yan, LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538.
APA Liu, YL,Liang, JH,Yan, LD,Su, RB,Wu, CF,&Gong, ZH.(2005).Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.ACTA PHARMACOLOGICA SINICA,26(5),533-538.
MLA Liu, YL,et al."Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice".ACTA PHARMACOLOGICA SINICA 26.5(2005):533-538.
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