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学科主题临床医学
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
Guo, Guangwu1; Gui, Yaoting2; Gao, Shengjie1; Tang, Aifa2,3; Hu, Xueda1; Huang, Yi2,3; Jia, Wenlong1; Li, Zesong2,3; He, Minghui1; Sun, Liang2; Song, Pengfei1; Sun, Xiaojuan3; Zhao, Xiaokun4; Yang, Sangming1; Liang, Chaozhao5; Wan, Shengqing1; Zhou, Fangjian6; Chen, Chao1; Zhu, Jialou1,7; Li, Xianxin2; Jian, Minghan1; Zhou, Liang2; Ye, Rui1; Huang, Peide1; Chen, Jing2; Jiang, Tao1; Liu, Xiao1; Wang, Yong2; Zou, Jing1; Jiang, Zhimao2; Wu, Renhua1; Wu, Song2; Fan, Fan1; Zhang, Zhongfu2; Liu, Lin1; Yang, Ruilin2; Liu, Xingwang1; Wu, Haibo1; Yin, Weihua2; Zhao, Xia1; Liu, Yuchen2; Peng, Huanhuan1; Jiang, Binghua2; Feng, Qingxin2; Li, Cailing2; Xie, Jun2; Lu, Jingxiao2; Kristiansen, Karsten1,8; Li, Yingrui1; Zhang, Xiuqing1; Li, Songgang1; Wang, Jian1; Yang, Huanming1; Cai, Zhiming2,3; Wang, Jun1,8,9
刊名NATURE GENETICS
2012
DOI10.1038/ng.1014
44期:1页:17-19
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Chinese 863 program ; Shenzhen Municipal Government of China ; Promotion Program for Shenzhen Key Laboratory, Shenzhen, China ; Biobank of Complex Diseases in Shenzhen ; Shenzhen municipal government ; local government of the Yantian District of Shenzhen ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Chinese 863 program ; Shenzhen Municipal Government of China ; Promotion Program for Shenzhen Key Laboratory, Shenzhen, China ; Biobank of Complex Diseases in Shenzhen ; Shenzhen municipal government ; local government of the Yantian District of Shenzhen
研究领域[WOS]Genetics & Heredity
关键词[WOS]SOMATIC MUTATIONS ; CANCER
英文摘要

We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1 alpha and HIF2 alpha in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.

语种英语
所属项目编号2011CB809200 ; 30725008 ; 30890032 ; 30811130531 ; 2006AA02A301 ; 2006AA02A302 ; 2009AA022707 ; JC200903190767A ; JC200903190772A ; ZYC200903240076A ; CXB200903110066A ; ZYC200903240077A ; ZYC200903240080A ; CXB200903090055A ; CXB201005250016A ; CXC201005260001A
资助者National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Chinese 863 program ; Shenzhen Municipal Government of China ; Promotion Program for Shenzhen Key Laboratory, Shenzhen, China ; Biobank of Complex Diseases in Shenzhen ; Shenzhen municipal government ; local government of the Yantian District of Shenzhen ; National Basic Research Program of China (973 program) ; National Natural Science Foundation of China ; Chinese 863 program ; Shenzhen Municipal Government of China ; Promotion Program for Shenzhen Key Laboratory, Shenzhen, China ; Biobank of Complex Diseases in Shenzhen ; Shenzhen municipal government ; local government of the Yantian District of Shenzhen
WOS记录号WOS:000298664000007
Citation statistics
Cited Times:141[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60149
Collection北京大学深圳医院_泌尿外科
作者单位1.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
2.Univ Copenhagen, Dept Biol, Copenhagen, Denmark
3.BGI Shenzhen, Shenzhen Key Lab Trans Biotechnol, Shenzhen, Peoples R China
4.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol, Shenzhen Hosp,Shenzhen PKU HKUST Med Ctr, Shenzhen, Peoples R China
5.Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Shenzhen, Peoples R China
6.Central So Univ, Xiangya Hosp 2, Dept Urol, Changsha, Peoples R China
7.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
8.Sun Yat Sen Univ, Ctr Canc, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China
9.Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark
Recommended Citation
GB/T 7714
Guo, Guangwu,Gui, Yaoting,Gao, Shengjie,et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma[J]. NATURE GENETICS,2012,44(1):17-19.
APA Guo, Guangwu.,Gui, Yaoting.,Gao, Shengjie.,Tang, Aifa.,Hu, Xueda.,...&Wang, Jun.(2012).Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.NATURE GENETICS,44(1),17-19.
MLA Guo, Guangwu,et al."Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma".NATURE GENETICS 44.1(2012):17-19.
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