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学科主题临床医学
Comparison of intra-articular low-dose sufentanil, ropivacaine, and combined sufentanil and ropivacaine on post-operative analgesia of isolated anterior cruciate ligament reconstruction
Wang, Xin1; Jia, Donglin2; Chen, Xiuyun1; Xu, Yan1
关键词Sufentanil Ropivacaine Anterior cruciate ligament reconstruction Intra-articular
刊名KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
2013-05-01
DOI10.1007/s00167-012-2326-6
21期:5页:1140-1145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Sport Sciences ; Surgery
研究领域[WOS]Orthopedics ; Sport Sciences ; Surgery
关键词[WOS]ARTHROSCOPIC KNEE SURGERY ; ARTICULAR CHONDROCYTES ; PAIN MANAGEMENT ; 0.5-PERCENT BUPIVACAINE ; MORPHINE ; EFFICACY ; REPLACEMENT ; INJECTION ; LIDOCAINE ; INFUSION
英文摘要

To evaluate the effect of combined local anaesthetic and opioid in post-operative analgesia, the effect of intra-articular injection of local anaesthetic (ropivacaine), opioid (sufentanil) and combination of these two (ropivacaine combined with sufentanil) after the single-bundle anterior cruciate ligament reconstruction were compared.

In a prospective randomized double-blind design, 80 patients who underwent isolated anterior cruciate ligament reconstruction under epidural analgesia were randomly allocated to 4 groups, group A (n = 20) received 30 mL of 0.9 % saline as the control group, group B (n = 20) received 10 mg ropivacaine and 2 mu g sufentanil in 30 mL 0.9 % saline, group C (n = 20) received 10 mg ropivacaine in 30 mL 0.9 % saline, group D (n = 20) received 2 mu g sufentanil in 30 mL 0.9 % saline at the end of the operation. Pain was assessed by use of a 100-mm visual analogue scale (VAS) which was evaluated at 6 and 24 h post-operation. The pain VAS score in active straight leg raising exercise, sleep quality and the status of the administered supplementary analgesia drugs during the first 24 h were also collected.

Pain scores of each of the three experiment groups were significantly lower than the control group in every aspect. Group B (ropivacaine with sufentanil) had significant lower pain score than group C (ropivacaine) and group D (sufentanil) both at 6 and 24 h after the operation. Patients in group B, C or D showed significant better sleep qualities than group A. Significantly more patients in group A received supplementary analgesia than group B, C or D. In group B, no patient needed to receive intramuscular dolantin as supplementary analgesia.

Intra-articular injection of opioid (sufentanil), local anaesthetic (ropivacaine) or combination of these two kinds of agents could significantly reduce the pain following the reconstruction of anterior cruciate ligament. The combined intra-articular injection of opioid and local anaesthetic provided better analgesia effect than using sufentanil or ropivacaine alone.

Randomized controlled trial, Level I.

语种英语
WOS记录号WOS:000317978400021
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60151
专题北京大学第三临床医学院_运动医学研究所
北京大学第三临床医学院_疼痛科
作者单位1.Peking Univ, Inst Sports Med, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Anesthesia, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xin,Jia, Donglin,Chen, Xiuyun,et al. Comparison of intra-articular low-dose sufentanil, ropivacaine, and combined sufentanil and ropivacaine on post-operative analgesia of isolated anterior cruciate ligament reconstruction[J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,2013,21(5):1140-1145.
APA Wang, Xin,Jia, Donglin,Chen, Xiuyun,&Xu, Yan.(2013).Comparison of intra-articular low-dose sufentanil, ropivacaine, and combined sufentanil and ropivacaine on post-operative analgesia of isolated anterior cruciate ligament reconstruction.KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,21(5),1140-1145.
MLA Wang, Xin,et al."Comparison of intra-articular low-dose sufentanil, ropivacaine, and combined sufentanil and ropivacaine on post-operative analgesia of isolated anterior cruciate ligament reconstruction".KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 21.5(2013):1140-1145.
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