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Attenuating Immune Response of Macrophage by Enhancing Hydrophilicity of Ti Surface
Dai, Xiaohan1,2; Wei, Yan2; Zhang, Xuehui3; Meng, Song2; Mo, Xiaoju2; Liu, Xing; Deng, Xuliang2,4; Zhang, Li5; Deng, Xuming
刊名JOURNAL OF NANOMATERIALS
2015
DOI10.1155/2015/712810
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]BETA-TRICALCIUM PHOSPHATE ; FOREIGN-BODY REACTION ; TITANIUM SURFACE ; CELL-SHAPE ; EXPRESSION ; PATHWAY ; OSSEOINTEGRATION ; BIOMATERIALS ; INHIBITION ; ACTIVATION
英文摘要

Immune responses can determine the in vivo fate of implanted materials. The strategy for developing implants has shifted towards using materials with immunomodulatory activity. However, the immunoregulatory effect of hydrophilicity of titanium surface on themacrophage behavior and its underlying mechanism remain poorly understood. Here, the Ti surface hydrophilicity-dependent behavior of murine RAW264.7 macrophages was investigated in vitro. Two laboratory models with significantly different surface hydrophilicity and similar roughness were established with Ti-polished and Ti-H2O2 surfaces. The results of cell morphology observation showed that the Ti-H2O2 surface yielded enhanced cell adhesion and less multinucleated cell formation. CCK-8 assay indicated that the growth rate of macrophage on Ti-H2O2 surface is higher than that of Ti-polished. ELISA assay result revealed lower level of proinflammatory factor TNF-alpha and higher level of anti-inflammatory factor IL-10 on the Ti-H2O2 surface compared to Ti-polished. Subsequently, immunofluorescence and western blotting analysis showed that activation of the NF-kappa B-TNF-alpha pathway might be involved in the modulation of the immune response by surface hydrophilicity. Together, these results suggested that relative high hydrophilic Ti surface might attenuate the immune response of macrophage by activating NF-kappa B signaling. These findings could provide new insights into designing implant devices for orthopedic applications.

语种英语
WOS记录号WOS:000354675900001
项目编号2012CB933900 ; 7144256 ; 7144257 ; 20130001120112 ; Z14111000180000
资助机构National Basic Research Program of China ; Beijing Natural Science Foundation ; Doctoral Scientific Fund Project of the Ministry of Education of China ; Beijing Nova program
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60153
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_特诊科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 2, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Clin Div 1, Beijing 100034, Peoples R China
5.Sichuan Univ, Res Ctr Nanobiomat, Analyt & Testing Ctr, Chengdu 610064, Peoples R China
推荐引用方式
GB/T 7714
Dai, Xiaohan,Wei, Yan,Zhang, Xuehui,et al. Attenuating Immune Response of Macrophage by Enhancing Hydrophilicity of Ti Surface[J]. JOURNAL OF NANOMATERIALS,2015.
APA Dai, Xiaohan.,Wei, Yan.,Zhang, Xuehui.,Meng, Song.,Mo, Xiaoju.,...&Deng, Xuming.(2015).Attenuating Immune Response of Macrophage by Enhancing Hydrophilicity of Ti Surface.JOURNAL OF NANOMATERIALS.
MLA Dai, Xiaohan,et al."Attenuating Immune Response of Macrophage by Enhancing Hydrophilicity of Ti Surface".JOURNAL OF NANOMATERIALS (2015).
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