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学科主题: 临床医学
题名:
Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer
作者: Zha, Zhengbao3; Wang, Jinrui1,2; Zhang, Shuhai3; Wang, Shumin1,2; Qu, Enze1,2; Zhang, Youyi1,2; Dai, Zhifei1,2
关键词: Oil-in-water emulsion ; Polypyrrole capsules ; Perfluorooctylbromide ; Ultrasound imaging ; Photothermal therapy
刊名: BIOMATERIALS
发表日期: 2014
DOI: 10.1016/j.biomaterials.2013.09.084
卷: 35, 期:1, 页:287-293
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: COPPER SULFIDE NANOPARTICLES ; GOLD NANOCAGES ; THERAPY ; ABLATION ; CELLS ; AGENT ; DESTRUCTION ; MICELLES ; DELIVERY ; UNIFORM
英文摘要:

A versatile oil-in-water emulsion method has been explored for constructing water-dispersible polypyrrole (PPy) nano-/microcapsules with a soluble PPy complex as multifunctional photothermal agents for tumor ablation. In this work, both PPy nanocapsules (280.4 +/- 79.0 nm) and microcapsules (1.31 +/- 0.45 mu m) with liquid perfluorooctylbromide (PFOB) core could be obtained by simply tuning the process energy for emulsion formation from ultrasonication to homogenization. Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. Thus, it is anticipated that fine-tuning of the other encapsulated drugs or functional materials in PPy capsules would foster avenues for the development of multifunctional platforms for cancer treatments. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81225011 ; 81230036 ; 21273014 ; 81371580
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号: WOS:000328006100028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60161
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

Recommended Citation:
Zha, Zhengbao,Wang, Jinrui,Zhang, Shuhai,et al. Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer[J]. BIOMATERIALS,2014,35(1):287-293.
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