IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer
Zha, Zhengbao3; Wang, Jinrui1,2; Zhang, Shuhai3; Wang, Shumin1,2; Qu, Enze1,2; Zhang, Youyi1,2; Dai, Zhifei1,2
关键词Oil-in-water emulsion Polypyrrole capsules Perfluorooctylbromide Ultrasound imaging Photothermal therapy
刊名BIOMATERIALS
2014
DOI10.1016/j.biomaterials.2013.09.084
35期:1页:287-293
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]COPPER SULFIDE NANOPARTICLES ; GOLD NANOCAGES ; THERAPY ; ABLATION ; CELLS ; AGENT ; DESTRUCTION ; MICELLES ; DELIVERY ; UNIFORM
英文摘要

A versatile oil-in-water emulsion method has been explored for constructing water-dispersible polypyrrole (PPy) nano-/microcapsules with a soluble PPy complex as multifunctional photothermal agents for tumor ablation. In this work, both PPy nanocapsules (280.4 +/- 79.0 nm) and microcapsules (1.31 +/- 0.45 mu m) with liquid perfluorooctylbromide (PFOB) core could be obtained by simply tuning the process energy for emulsion formation from ultrasonication to homogenization. Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. Thus, it is anticipated that fine-tuning of the other encapsulated drugs or functional materials in PPy capsules would foster avenues for the development of multifunctional platforms for cancer treatments. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81225011 ; 81230036 ; 21273014 ; 81371580
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号WOS:000328006100028
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60161
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
Recommended Citation
GB/T 7714
Zha, Zhengbao,Wang, Jinrui,Zhang, Shuhai,et al. Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer[J]. BIOMATERIALS,2014,35(1):287-293.
APA Zha, Zhengbao.,Wang, Jinrui.,Zhang, Shuhai.,Wang, Shumin.,Qu, Enze.,...&Dai, Zhifei.(2014).Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer.BIOMATERIALS,35(1),287-293.
MLA Zha, Zhengbao,et al."Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer".BIOMATERIALS 35.1(2014):287-293.
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