|Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China|
|Li, Zhiwen1,2; Zhang, Le1,2; Ye, Rongwei1,2; Liu, Jianmeng1,2; Pei, Lijun3; Zheng, Xiaoying3; Ren, Aiguo1,2|
|关键词||Partner smoking secondhand smoke neural tube defects socioeconomic status low middle-income country smoking-caused disease|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||MATERNAL SMOKING ; CONGENITAL-MALFORMATIONS ; TOBACCO-SMOKE ; FOLATE LEVELS ; EXPOSURE ; SELF ; POPULATION ; PREVALENCE ; CADMIUM ; ALCOHOL|
Objectives To investigate the effect of secondhand smoke exposure from a partner on the risk of having a newborn baby with neural tube defects (NTDs) in Chinese non-smoking women.
Methods Data were derived from an on-going population-based case-control study of external malformations in northern China. The case group included 580 infants or fetuses with NTDs identified between November 2002 and December 2007. Controls were 795 newborn infants without major external malformations. Data were collected by trained health workers through face-to-face interviews within 1week after delivery.
Results A total of 81.4% of partners of case women and 71.8% of partners of control women smoked during the women′s peri-conceptional period. The adjusted OR for NTDs associated with partner smoking was 1.6 (95% CI 1.2 to 2.1). Compared with non-smoking women with non-smoking partners, fetal NTD risk among women with smoking partners was 1.7 (1.3 to 2.4) and 1.1 (0.7 to 1.7) for women exposed and not exposed to partner smoking, respectively. Among women who were exposed to partner smoking, the risk of NTDs was 1.4 (0.9 to 2.0), 1.8 (1.2 to 2.6), 1.9 (1.2 to 3.0) and 2.7 (1.6 to 4.7) for partner smoking of <1, 1-9, 10-19 and 20/day, respectively (p for trend <0.001).
Conclusion Peri-conceptional exposure to partner smoking may increase the risk of NTDs in the offspring of Chinese non-smoking women.
|项目编号||31071315 ; 2007CB5119001|
|资助机构||National Natural Science Foundation of China ; State Key Development Program for Basic Research, People&prime ; s Republic of China|
|作者单位||1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China|
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
3.Peking Univ, Inst Populat Res, WHO Collaborating Ctr Reprod Hlth & Populat Sci, Beijing 100191, Peoples R China
|Li, Zhiwen,Zhang, Le,Ye, Rongwei,et al. Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China[J]. TOBACCO CONTROL,2013,22(6):401-405.|
|APA||Li, Zhiwen.,Zhang, Le.,Ye, Rongwei.,Liu, Jianmeng.,Pei, Lijun.,...&Ren, Aiguo.(2013).Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China.TOBACCO CONTROL,22(6),401-405.|
|MLA||Li, Zhiwen,et al."Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China".TOBACCO CONTROL 22.6(2013):401-405.|