IR@PKUHSC  > 北京大学公共卫生学院  > 北京大学生育健康研究所
学科主题公共卫生
Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China
Li, Zhiwen1,2; Zhang, Le1,2; Ye, Rongwei1,2; Liu, Jianmeng1,2; Pei, Lijun3; Zheng, Xiaoying3; Ren, Aiguo1,2
关键词Partner smoking secondhand smoke neural tube defects socioeconomic status low middle-income country smoking-caused disease
刊名TOBACCO CONTROL
2013-11-01
DOI10.1136/tobaccocontrol-2011-050384
22期:6页:401-405
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
资助者National Natural Science Foundation of China ; State Key Development Program for Basic Research, People&prime ; s Republic of China ; National Natural Science Foundation of China ; State Key Development Program for Basic Research, People&prime ; s Republic of China
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]MATERNAL SMOKING ; CONGENITAL-MALFORMATIONS ; TOBACCO-SMOKE ; FOLATE LEVELS ; EXPOSURE ; SELF ; POPULATION ; PREVALENCE ; CADMIUM ; ALCOHOL
英文摘要

Objectives To investigate the effect of secondhand smoke exposure from a partner on the risk of having a newborn baby with neural tube defects (NTDs) in Chinese non-smoking women.

Methods Data were derived from an on-going population-based case-control study of external malformations in northern China. The case group included 580 infants or fetuses with NTDs identified between November 2002 and December 2007. Controls were 795 newborn infants without major external malformations. Data were collected by trained health workers through face-to-face interviews within 1week after delivery.

Results A total of 81.4% of partners of case women and 71.8% of partners of control women smoked during the women′s peri-conceptional period. The adjusted OR for NTDs associated with partner smoking was 1.6 (95% CI 1.2 to 2.1). Compared with non-smoking women with non-smoking partners, fetal NTD risk among women with smoking partners was 1.7 (1.3 to 2.4) and 1.1 (0.7 to 1.7) for women exposed and not exposed to partner smoking, respectively. Among women who were exposed to partner smoking, the risk of NTDs was 1.4 (0.9 to 2.0), 1.8 (1.2 to 2.6), 1.9 (1.2 to 3.0) and 2.7 (1.6 to 4.7) for partner smoking of <1, 1-9, 10-19 and 20/day, respectively (p for trend <0.001).

Conclusion Peri-conceptional exposure to partner smoking may increase the risk of NTDs in the offspring of Chinese non-smoking women.

语种英语
所属项目编号31071315 ; 2007CB5119001
资助者National Natural Science Foundation of China ; State Key Development Program for Basic Research, People&prime ; s Republic of China ; National Natural Science Foundation of China ; State Key Development Program for Basic Research, People&prime ; s Republic of China
WOS记录号WOS:000326107800013
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60168
Collection北京大学公共卫生学院_北京大学生育健康研究所
作者单位1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
3.Peking Univ, Inst Populat Res, WHO Collaborating Ctr Reprod Hlth & Populat Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhiwen,Zhang, Le,Ye, Rongwei,et al. Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China[J]. TOBACCO CONTROL,2013,22(6):401-405.
APA Li, Zhiwen.,Zhang, Le.,Ye, Rongwei.,Liu, Jianmeng.,Pei, Lijun.,...&Ren, Aiguo.(2013).Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China.TOBACCO CONTROL,22(6),401-405.
MLA Li, Zhiwen,et al."Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China".TOBACCO CONTROL 22.6(2013):401-405.
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