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学科主题: 临床医学
题名:
Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis
作者: Wu, LL; Tang, C; Liu, MS
关键词: myofibrillar Mg2+-adenosinetriphosphatase ; myosin light chain ; protein phosphorylation ; troponin
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
发表日期: 2001-08-01
卷: 281, 期:2, 页:R408-R416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology
研究领域[WOS]: Physiology
关键词[WOS]: TROPONIN-I ; MYOSIN PHOSPHORYLATION ; SEPTIC SHOCK ; C-PROTEIN ; RAT-HEART ; DYSFUNCTION ; FAILURE ; CONTRACTION ; ENDOTOXIN ; BINDING
英文摘要:

Altered phosphorylation and Ca2+ sensitivity of cardiac myofibrillar proteins during different phases of sepsis were investigated. Sepsis was induced by cecal ligation and puncture (CLP). The results show that phosphorylation of troponin I (TnI) was increased by 268% during the early phase (9 h after CLP) but decreased by 46% during the late phase (18 h after CLP) of sepsis. Phosphorylation of C protein was increased by 76% during the early phase but decreased by 41% during the late phase of sepsis. Phosphorylation of myosin light chain-2 (MLC-2) remained unaltered during the early phase but was decreased by 38% during the late phase of sepsis. Phosphorylation of TnT was unaffected during the progression of sepsis. The increases in the phosphorylation of TnI and C protein during early sepsis were associated with the decrease in the Ca2+ sensitivity of myofilaments and the increases in myocardial changes in tension development (+dP/dt(max)) and cAMP level. The decreases in the phosphorylation of TnI and C protein during late sepsis coincided with the declines in the activities of myofibrillar ATPase, Ca2+ sensitivity of myofilaments, myocardial +dP/dt(max), and cAMP content. The increases and the decreases in the phosphorylation of TnI and C protein, +dP/dt(max), and the tissue cAMP level were sensitive to isoproterenol stimulation and propranolol inhibition. These findings suggest that alterations in the phosphorylation of myofibrillar proteins, such as TnI, C protein, and MLC-2, and changes in the activities and the Ca2+ sensitivity of myofibrillar ATPase may contribute to the altered cardiac function during the progression of sepsis. Furthermore, the sepsis-induced alterations in the phosphorylation and Ca2+ sensitivity of cardiac myofibrillar proteins were mediated via a beta -adrenergic receptor pathway.

语种: 英语
WOS记录号: WOS:000169901500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60174
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China

Recommended Citation:
Wu, LL,Tang, C,Liu, MS. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY,2001,281(2):R408-R416.
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