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学科主题: 临床医学
题名:
Complete Blood Count Reference Intervals for Healthy Han Chinese Adults
作者: Wu, Xinzhong1; Zhao, Min2; Pan, Baishen3; Zhang, Jie4; Peng, Mingting5; Wang, Lanlan6; Hao, Xiaoke7; Huang, Xianzhang1; Mu, Runqing2; Guo, Wei3; Qiao, Rui4; Chen, Wenxiang5; Jiang, Hong6; Ma, Yueyun7; Shang, Hong2
刊名: PLOS ONE
发表日期: 2015-03-13
DOI: 10.1371/journal.pone.0119669
卷: 10, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BETA-THALASSEMIA ; REFERENCE VALUES ; POPULATION ; WOMEN
英文摘要:

Background

Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods

A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi′an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results

Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion

We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

语种: 英语
所属项目编号: 2012BAI37B01
项目资助者: National Key Technologies R&amp ; D Program of China
WOS记录号: WOS:000351277500091
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60178
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China
2.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
3.China Med Univ, Affiliated Hosp 1, Dept Clin Lab Med, Shenyang 110001, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Clin Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China
6.Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Sichuan, Peoples R China
7.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Lab Med, Xian 710032, Shaanxi, Peoples R China

Recommended Citation:
Wu, Xinzhong,Zhao, Min,Pan, Baishen,et al. Complete Blood Count Reference Intervals for Healthy Han Chinese Adults[J]. PLOS ONE,2015,10(3).
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