|Complete Blood Count Reference Intervals for Healthy Han Chinese Adults|
|Wu, Xinzhong1; Zhao, Min2; Pan, Baishen3; Zhang, Jie4; Peng, Mingting5; Wang, Lanlan6; Hao, Xiaoke7; Huang, Xianzhang1; Mu, Runqing2; Guo, Wei3; Qiao, Rui4; Chen, Wenxiang5; Jiang, Hong6; Ma, Yueyun7; Shang, Hong2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||BETA-THALASSEMIA ; REFERENCE VALUES ; POPULATION ; WOMEN|
Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.
A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi′an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.
Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.
We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.
|资助机构||National Key Technologies R& ; D Program of China|
|作者单位||1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China|
2.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
3.China Med Univ, Affiliated Hosp 1, Dept Clin Lab Med, Shenyang 110001, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Clin Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China
6.Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Sichuan, Peoples R China
7.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Lab Med, Xian 710032, Shaanxi, Peoples R China
|Wu, Xinzhong,Zhao, Min,Pan, Baishen,et al. Complete Blood Count Reference Intervals for Healthy Han Chinese Adults[J]. PLOS ONE,2015,10(3).|
|APA||Wu, Xinzhong.,Zhao, Min.,Pan, Baishen.,Zhang, Jie.,Peng, Mingting.,...&Shang, Hong.(2015).Complete Blood Count Reference Intervals for Healthy Han Chinese Adults.PLOS ONE,10(3).|
|MLA||Wu, Xinzhong,et al."Complete Blood Count Reference Intervals for Healthy Han Chinese Adults".PLOS ONE 10.3(2015).|