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Biotransformation of 4,5-O-dicaffeoylquinic acid methyl ester by human intestinal flora and evaluation on their inhibition of NO production and antioxidant activity of the products
Yang, Xiu-Wei; Wang, Nan; Li, Wei; Xu, Wei; Wu, Shuai
关键词4,5-O-Dicaffeoylquinic acid methyl ester Trans-caffeic acid Human intestinal flora Biotransformation Nitric oxide Antioxidant activity
刊名FOOD AND CHEMICAL TOXICOLOGY
2013-05-01
DOI10.1016/j.fct.2012.12.039
55页:297-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology ; Toxicology
研究领域[WOS]Food Science & Technology ; Toxicology
关键词[WOS]AMERICAN-DIETETIC-ASSOCIATION ; CHLOROGENIC ACIDS ; CAFFEIC ACID ; NITRIC-OXIDE ; LC-MSN ; DERIVATIVES ; METABOLISM ; ABSORPTION ; POSITION ; HEALTH
英文摘要

4,5-O-Dicaffeoylquinic acid methyl ester (1) was anaerobically incubated with human intestinal flora and four biotransformation products (2-5) were obtained. Their structures were elucidated as 3,4-O-dicaffeoylquinic acid methyl ester (2), 3-hydroxyphenylpropionic acid (3), trans-caffeic acid (4) and 3,4-dihydroxyphenylpropionic acid (5) on the basis of their spectroscopic data. Using high-performance liquid chromatography equipped with a diode array detector, chromatographic separation of 1-5 was performed on an analytical C-18 column. The time course of the biotransformation was studied to probe into the biotransformation mechanism of 1 by human intestinal flora. In addition, the inhibitory activity of the parent compound 1 and its four main biotransformation products 2-5 on the inhibition of nitric oxide production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and their DPPH free radical-scavenging activity in cell-free bioassay system were estimated. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000317536900039
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60185
专题北京大学药学院_天然药物学系
作者单位Peking Univ, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Xiu-Wei,Wang, Nan,Li, Wei,et al. Biotransformation of 4,5-O-dicaffeoylquinic acid methyl ester by human intestinal flora and evaluation on their inhibition of NO production and antioxidant activity of the products[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,55:297-303.
APA Yang, Xiu-Wei,Wang, Nan,Li, Wei,Xu, Wei,&Wu, Shuai.(2013).Biotransformation of 4,5-O-dicaffeoylquinic acid methyl ester by human intestinal flora and evaluation on their inhibition of NO production and antioxidant activity of the products.FOOD AND CHEMICAL TOXICOLOGY,55,297-303.
MLA Yang, Xiu-Wei,et al."Biotransformation of 4,5-O-dicaffeoylquinic acid methyl ester by human intestinal flora and evaluation on their inhibition of NO production and antioxidant activity of the products".FOOD AND CHEMICAL TOXICOLOGY 55(2013):297-303.
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