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学科主题: 临床医学
题名:
Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer
作者: Guo, Yi; Fu, Pingfu3; Zhu, Honglan4; Reed, Eddie5; Remick, Scot C.; Petros, William1,2; Mueller, Michael D.; Yu, Jing Jie1,2
关键词: gene signature ; epithelial ovarian cancer ; histological subtypes ; expression pattern
刊名: ONCOLOGY REPORTS
发表日期: 2012
DOI: 10.3892/or.2011.1483
卷: 27, 期:1, 页:286-292
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANDIDATE MOLECULAR MARKERS ; MESSENGER-RNA LEVELS ; EXPRESSION PROFILES ; REPAIR PATHWAY ; CELL-LINES ; RESISTANCE ; TUMORS ; IDENTIFICATION ; CARCINOMA ; UBC9
英文摘要:

The aim of this study was to better understand the mechanisms of tumor development and disease progression in human epithelial ovarian cancer. Fifty genes were screened for gene signature; 20 expressed genes were assessed in tumor and normal samples of EOC patients by RT-PCR. Expression of UBE2I, EGF, TAL2 and ILF3 was validated by qPCR on the ABI PRISM 7000 Detection System. ERCC I and XPB expression was previously determined by RT-PCR in these specimens. Statistical analyses include two-sided Kruskal-Wallis test, pairwise comparison, Pearson correlation coefficient and paired t-test. In comparison to normal samples, 6 genes demonstrated distinct expression patterns in tumor tissues, with high expression observed for ERCC I, XPB and ILF3 (p=0.001, 0.0007 and 0.002, respectively) and low expression observed for TAL2 and EGF (both p<0.0001). This differential expression pattern between normal and tumor tissues may reflect in part the development of ovarian cancer. Significant differences in expression patterns of these genes in clear cell, endometrioid, mucinous and serous ovarian cancer were observed. Comparison of expression of any two EOC subtypes revealed multiple gene involvement in histopathological differentiation and cancer progression. A positive association was found between ERCC1 and XPB expression (r=0.53, p<0.0001) and between TAL2 and EGF expression (r=0.817, p<0.0001) suggesting the existence of gene linkage in these tumors. The differences in expression patterns of studied genes between tumors and normal specimens, between histological subtypes and correlations among studied genes, may indicate their involvement in tumor growth and disease progression in human epithelial ovarian cancer. Further investigation of these genes may enable better understanding of the molecular mechanism of tumorigenesis and identification of potential biomarkers.

语种: 英语
WOS记录号: WOS:000297397500040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60186
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Mary Babb Randolph Canc Ctr, Dept Biochem,Sch Med, Morgantown, WV 26506 USA
2.W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Dept Basic Pharmaceut Sci, Sch Pharm, Morgantown, WV 26506 USA
3.Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
4.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
5.USA Mitchell Canc Inst, Mobile, AL USA

Recommended Citation:
Guo, Yi,Fu, Pingfu,Zhu, Honglan,et al. Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer[J]. ONCOLOGY REPORTS,2012,27(1):286-292.
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