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学科主题临床医学
The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination
Liu, Tao; Zhang, Qian; Wang, Lingling; Yu, Lu; Leng, Wenchuan; Yang, Jian; Chen, Lihong; Peng, Junping; Ma, Li; Dong, Jie; Xu, Xingye; Xue, Ying; Zhu, Yafang; Zhang, Wenliang; Yang, Li; Li, Weijun; Sun, Lilian; Wan, Zhe; Ding, Guohui; Yu, Fudong; Tu, Kang; Qian, Ziliang; Li, Ruoyu; Shen, Yan; Li, Yixue; Jin, Qi
刊名BMC GENOMICS
2007-04-11
DOI10.1186/1471-2164-8-100
8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]PROTEIN-COUPLED RECEPTOR ; FUNGAL SPORE GERMINATION ; SACCHAROMYCES-CEREVISIAE ; NEUROSPORA-CRASSA ; ASPERGILLUS-NIDULANS ; RIBONUCLEIC-ACID ; YEAST ; PATHWAY ; GROWTH ; GENOME
英文摘要

Background: Conidia are considered to be the primary cause of infections by Trichophyton rubrum.

Results: We have developed a cDNA microarray containing 10250 ESTs to monitor the transcriptional strategy of conidial germination. A total of 1561 genes that had their expression levels specially altered in the process were obtained and hierarchically clustered with respect to their expression profiles. By functional analysis, we provided a global view of an important biological system related to conidial germination, including characterization of the pattern of gene expression at sequential developmental phases, and changes of gene expression profiles corresponding to morphological transitions. We matched the EST sequences to GO terms in the Saccharomyces Genome Database ( SGD). A number of homologues of Saccharomyces cerevisiae genes related to signalling pathways and some important cellular processes were found to be involved in T. rubrum germination. These genes and signalling pathways may play roles in distinct steps, such as activating conidial germination, maintenance of isotropic growth, establishment of cell polarity and morphological transitions.

Conclusion: Our results may provide insights into molecular mechanisms of conidial germination at the cell level, and may enhance our understanding of regulation of gene expression related to the morphological construction of T. rubrum.

语种英语
WOS记录号WOS:000246705000001
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60189
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China
2.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
3.Chinese Ctr Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, Inst Viral Dis Control & Prevent, Beijing 100176, Peoples R China
4.Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China
5.Jilin Univ, Coll Life Sci, Changchun 130012, Jilin Province, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Biol Sci, Bioinformat Ctr, Shanghai 200031, Peoples R China
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GB/T 7714
Liu, Tao,Zhang, Qian,Wang, Lingling,et al. The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination[J]. BMC GENOMICS,2007,8.
APA Liu, Tao.,Zhang, Qian.,Wang, Lingling.,Yu, Lu.,Leng, Wenchuan.,...&Jin, Qi.(2007).The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination.BMC GENOMICS,8.
MLA Liu, Tao,et al."The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germination".BMC GENOMICS 8(2007).
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