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学科主题: 临床医学
题名:
Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population
作者: Wang Fang; Han Xue-yao; Ren Qian; Zhang Xiu-ying; Han Ling-chuan; Luo Ying-ying; Zhou Xiang-hai; Ji Li-nong
关键词: type 2 diabetes ; KCNJ11 ; ABCC8 ; PPARG ; HNF4A
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-10-20
DOI: 10.3760/cma.j.issn.0366-6999.2009.20.015
卷: 122, 期:20, 页:2477-2482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GENOME-WIDE ASSOCIATION ; FACTOR-4-ALPHA P2 PROMOTER ; BETA-CELL FUNCTION ; SULFONYLUREA RECEPTOR ; PRO12ALA POLYMORPHISM ; INSULIN SENSITIVITY ; JAPANESE POPULATION ; DECREASED RISK ; CHROMOSOME 20Q ; RESISTANCE
英文摘要:

Background KCNJ11, ABCC8, PPARG, and HNF4A have been found to be associated with type 2 diabetes in populations with different genetic backgrounds. The aim of this study was to test, in a Chinese Han population from Beijing, whether the genetic variants in these four genes were associated with genetic predisposition to type 2 diabetes.

Methods We studied the association of four representative SNPs in KCNJ11, ABCC8, PPARG and HNF4A by genotyping them using ABI SNaPshot(R) Multiplex System in 400 unrelated type 2 diabetic patients and 400 unrelated normoglycaemic subjects.

Results rs5219(E23K) in KG-NJ11 was associated with genetic susceptibility to type 2 diabetes (OR=1.400 with 95% Cl 1.117 1.755, P=0.004 under an additive model, OR=1.652 with 95% Cl 1.086 2.513, PL=0.019 under a recessive model, and OR=1.521 with 95% Cl 1.089 2.123, PL=0.014 under a dominant model) after adjusting for sex and body mass index (BMI). We did not find evidence of association for ABCC8 rs1799854, PPARG rs1801282 (Pro12Ala) and HNF4A rs2144908. Genotype-phenotype correlation analysis revealed that rs1799854 in ABCC8 was associated with 2-hour postprandial insulin secretion (P=0.005) after adjusting for sex, age and BMI. Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P=0.004 under an additive model for rs2144908; and P=0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.

Conclusions Our study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing. And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion. Chin Med J 2009;122(20):2477-2482

语种: 英语
所属项目编号: 2006AA02A409 ; 2006CB503900
项目资助者: National High Technology Research and Development Program ; National Basic Research Program of China
WOS记录号: WOS:000271367000015
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60191
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China

Recommended Citation:
Wang Fang,Han Xue-yao,Ren Qian,et al. Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population[J]. CHINESE MEDICAL JOURNAL,2009,122(20):2477-2482.
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