北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis
作者: Wu, Yu; Su, Tao; Yang, Li; Zhu, Sai-Nan; Li, Xiao-Mei
关键词: Neutrophil gelatinase-associated lipocalin ; Drug-induced chronic tubulointerstitial nephritis ; eGFR change rate ; Prognosis
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2010-06-01
DOI: 10.1097/MAJ.0b013e3181dd0cb1
卷: 339, 期:6, 页:537-542
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; ACUTE RENAL INJURY ; NGAL ; NEPHROPATHY ; SEVERITY ; CHILDREN ; DELIVERY
英文摘要:

Introduction: The role of urinary biomarkers of kidney injury in the prediction of adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described. Methods: A total of 36 patients with D-CTIN were enrolled in the study. The baseline urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL), alpha 1-microglobin (alpha 1-MG), albumin (mAlb) and total protein were measured, and estimated glomerular filtration rate change rates within a period of 6 to 33 (mean: 24 months) follow-up months were recorded. Results: Areas under the receiver-operator characteristic curve of urinary NGAL, alpha 1-MG, mAlb and total protein for predicting deterioration of estimated glomerular filtration rate were 0.707, 0.631, 0.685 and 0.678, respectively. The cutoff points that maximized the combined sensitivity and specificity for NGAL, alpha 1-MG, mAlb and total protein were 37.71 ng/mL, 33.20 mu g/mL, 6.91 mg/L and 60.00 mg/L, respectively. At these thresholds, the sensitivity and specificity was 64.7% and 78.9% for NGAL, 66.7% and 50.0% for alpha 1-MG, 80.0% and 50.0% for mAlb and 70.6% and 63.2% for total protein, respectively. The median renal survival time (years) of patients with urinary NGAL level exceeding 37.705 ng/mL was shorter than that of patients with urinary NGAL level below 37.705 ng/mL (1.59 +/- 0.79 versus 2.09 +/- 0.63, P = 0.040, chi(2) = 4.218). Conclusions: Increase of baseline urinary NGAL was better than alpha 1-MG, mAlb and total protein in predicting renal function deterioration in patients with D-CTIN. This noninvasive approach has potential to serve as a practical tool in D-CTIN prognosis.

语种: 英语
所属项目编号: 2007 BAI04B10
项目资助者: National Key Technologies RD Program
WOS记录号: WOS:000278464300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60195
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Div Renal,Minist Hlth China, Dept Med,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China

Recommended Citation:
Wu, Yu,Su, Tao,Yang, Li,et al. Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,339(6):537-542.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Yu]'s Articles
[Su, Tao]'s Articles
[Yang, Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Yu]‘s Articles
[Su, Tao]‘s Articles
[Yang, Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace