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Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis
Wu, Yu; Su, Tao; Yang, Li; Zhu, Sai-Nan; Li, Xiao-Mei
关键词Neutrophil gelatinase-associated lipocalin Drug-induced chronic tubulointerstitial nephritis eGFR change rate Prognosis
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2010-06-01
DOI10.1097/MAJ.0b013e3181dd0cb1
339期:6页:537-542
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CHRONIC KIDNEY-DISEASE ; ACUTE RENAL INJURY ; NGAL ; NEPHROPATHY ; SEVERITY ; CHILDREN ; DELIVERY
英文摘要

Introduction: The role of urinary biomarkers of kidney injury in the prediction of adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described. Methods: A total of 36 patients with D-CTIN were enrolled in the study. The baseline urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL), alpha 1-microglobin (alpha 1-MG), albumin (mAlb) and total protein were measured, and estimated glomerular filtration rate change rates within a period of 6 to 33 (mean: 24 months) follow-up months were recorded. Results: Areas under the receiver-operator characteristic curve of urinary NGAL, alpha 1-MG, mAlb and total protein for predicting deterioration of estimated glomerular filtration rate were 0.707, 0.631, 0.685 and 0.678, respectively. The cutoff points that maximized the combined sensitivity and specificity for NGAL, alpha 1-MG, mAlb and total protein were 37.71 ng/mL, 33.20 mu g/mL, 6.91 mg/L and 60.00 mg/L, respectively. At these thresholds, the sensitivity and specificity was 64.7% and 78.9% for NGAL, 66.7% and 50.0% for alpha 1-MG, 80.0% and 50.0% for mAlb and 70.6% and 63.2% for total protein, respectively. The median renal survival time (years) of patients with urinary NGAL level exceeding 37.705 ng/mL was shorter than that of patients with urinary NGAL level below 37.705 ng/mL (1.59 +/- 0.79 versus 2.09 +/- 0.63, P = 0.040, chi(2) = 4.218). Conclusions: Increase of baseline urinary NGAL was better than alpha 1-MG, mAlb and total protein in predicting renal function deterioration in patients with D-CTIN. This noninvasive approach has potential to serve as a practical tool in D-CTIN prognosis.

语种英语
WOS记录号WOS:000278464300008
项目编号2007 BAI04B10
资助机构National Key Technologies RD Program
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60195
专题北京大学第一临床医学院
北京大学第一临床医学院_放射治疗科
作者单位Peking Univ, Hosp 1, Div Renal,Minist Hlth China, Dept Med,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China
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GB/T 7714
Wu, Yu,Su, Tao,Yang, Li,et al. Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,339(6):537-542.
APA Wu, Yu,Su, Tao,Yang, Li,Zhu, Sai-Nan,&Li, Xiao-Mei.(2010).Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,339(6),537-542.
MLA Wu, Yu,et al."Urinary Neutrophil Gelatinase-Associated Lipocalin: A Potential Biomarker for Predicting Rapid Progression of Drug-Induced Chronic Tubulointerstitial Nephritis".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 339.6(2010):537-542.
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