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学科主题: 基础医学
题名:
Programmed cell death 10, beyond an apoptosis-related molecule
作者: Ma Xi; Zhao Hong-Shan; Ma Da-Long
关键词: programmed cell death 10(PDCD10) ; interaction protein ; MST4 ; cerebral cavernous malformations ; (CCM)
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2007-08-01
卷: 34, 期:8, 页:781-790
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CEREBRAL CAVERNOUS MALFORMATIONS ; PROTEIN INTERACTIONS ; STE20-RELATED KINASE ; CELL-MIGRATION ; CANCER CELLS ; GENE ; MUTATIONS ; MST4 ; PATHOGENESIS ; EXPRESSION
英文摘要:

Homo sapiens PDCD10 (programmed cell death 10, alias, "TF-1 cell apoptosis related gene 15, TFAR15"), cloned by means of cDNA-representational differences analysis, had been initially identified associated with cell apoptosis. Recent research suggested mutations within the PDCD10 gene or deletion were responsible for cerebral cavernous malformations, and PDCD10 was the third CCM gene. On the other hand, other research demonstrated that PDCD10 was strictly modulated and up regulated in many kinds of tumors, which implicated that PDCD10 participated in tumorous signal transduction. The recent research confirmed that PDCD10 interacts with MST4, a member of Ste20-related kinases, and the interaction promoted cell proliferation and transformation via modulation of the ERK-MARK pathway. In conclusion, all these demonstrate that PDCD10 has many biological effects, which suggests that it is a novel player in vascular morphogenesis and/or remodeling, as well as tumorigenesis and cancer progression.

语种: 中文
WOS记录号: WOS:000248758200001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60196
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med, Dept Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Human Dis Genom Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Ma Xi,Zhao Hong-Shan,Ma Da-Long. Programmed cell death 10, beyond an apoptosis-related molecule[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(8):781-790.
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