IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Programmed cell death 10, beyond an apoptosis-related molecule
Ma Xi; Zhao Hong-Shan; Ma Da-Long
关键词programmed cell death 10(PDCD10) interaction protein MST4 cerebral cavernous malformations (CCM)
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2007-08-01
34期:8页:781-790
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CEREBRAL CAVERNOUS MALFORMATIONS ; PROTEIN INTERACTIONS ; STE20-RELATED KINASE ; CELL-MIGRATION ; CANCER CELLS ; GENE ; MUTATIONS ; MST4 ; PATHOGENESIS ; EXPRESSION
英文摘要

Homo sapiens PDCD10 (programmed cell death 10, alias, "TF-1 cell apoptosis related gene 15, TFAR15"), cloned by means of cDNA-representational differences analysis, had been initially identified associated with cell apoptosis. Recent research suggested mutations within the PDCD10 gene or deletion were responsible for cerebral cavernous malformations, and PDCD10 was the third CCM gene. On the other hand, other research demonstrated that PDCD10 was strictly modulated and up regulated in many kinds of tumors, which implicated that PDCD10 participated in tumorous signal transduction. The recent research confirmed that PDCD10 interacts with MST4, a member of Ste20-related kinases, and the interaction promoted cell proliferation and transformation via modulation of the ERK-MARK pathway. In conclusion, all these demonstrate that PDCD10 has many biological effects, which suggests that it is a novel player in vascular morphogenesis and/or remodeling, as well as tumorigenesis and cancer progression.

语种中文
WOS记录号WOS:000248758200001
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60196
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Sch Basic Med, Dept Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Human Dis Genom Ctr, Beijing 100083, Peoples R China
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Ma Xi,Zhao Hong-Shan,Ma Da-Long. Programmed cell death 10, beyond an apoptosis-related molecule[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(8):781-790.
APA Ma Xi,Zhao Hong-Shan,&Ma Da-Long.(2007).Programmed cell death 10, beyond an apoptosis-related molecule.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,34(8),781-790.
MLA Ma Xi,et al."Programmed cell death 10, beyond an apoptosis-related molecule".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 34.8(2007):781-790.
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