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学科主题: 基础医学
题名:
LAPTM4B Overexpression is a Novel Independent Prognostic Marker for Metastatic Ovarian Tumors
作者: Yin, Mingzhu1; Lou, Chun2; Zhang, Wang3; Meng, Fanling1; Zhang, Haiyu3; Ning, Xiaoming4; Zhou, Rouli5; Dong, Xinshu2; Lou, Ge1
关键词: Immunohistochemistry ; LAPTM4B ; Metastatic ovarian tumor ; Survival
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2012
DOI: 10.1097/IGC.0b013e318234f9ac
卷: 22, 期:1, 页:54-62
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; GASTRIC-CANCER ; SURVIVAL ; PROTEIN ; TRACT
英文摘要:

Objective: Metastatic ovarian tumors are a series of lethal carcinomas that almost always have bad prognosis. Their prognoses, however, vary depending on the primary tumor malignancies of each. It has been reported that LAPTM4B, a novel tumor-associated gene, might indicate a worse prognosis when it was overexpressed in other carcinomas. Therefore, the authors expected to investigate whether LAPTM4B overexpression is an independent prognostic marker in metastatic ovarian tumors.

Methods: Immunohistochemistry was used to assess LAPTM4B expression in metastatic ovarian tumors from 102 patients. Subsequently, univariate and multivariate survival analyses with Cox regression were performed to determine the association between LAPTM4B expression and prognosis. To identify any differences in prognosis between the 2 groups of patients with differing primary malignancies, the log-rank test was used.

Results: The median overall and progression-free survival rates of patients with tumors of gastrointestinal tract origin were 0.97 and 0.51 years, respectively, and both were statistically significantly lower than those of patients with tumors of breast origin (P < 0.0001), which were 2.68 and 1.96 years, accordingly. Of 102 patients, 77 were classified as having a high expression of LAPTM4B, and LAPTM4B expression had a significant association with the prognosis of metastatic ovarian tumors (P < 0.01); no statistically significant interaction between LAPTM4B expression and primary malignancies was detected (P > 0.1). On the other hand, medians of overall survival and progression-free survival of patients with tumors of gastrointestinal tract origin were significantly lower than those of patients with tumors of breast origin (P < 0.0001).

Conclusions: Patients with metastatic ovarian tumors of breast origin had significantly better prognosis than those with the disease from gastrointestinal tract primary malignancies. LAPTM4B overexpression might be an independent prognostic marker of metastatic ovarian tumors.

语种: 英语
所属项目编号: 2006RFLXS022
项目资助者: Bureau of Science and Technology, Harbin, China
WOS记录号: WOS:000298628800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60201
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Harbin Med Univ, Tumor Hosp, Dept Gynecol Oncol, Harbin 150081, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin 150081, Peoples R China
3.Harbin Med Univ, Dept Biostat, Harbin 150081, Peoples R China
4.Harbin Med Univ, Tumor Hosp, Dept Pathol, Harbin 150081, Peoples R China
5.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Yin, Mingzhu,Lou, Chun,Zhang, Wang,et al. LAPTM4B Overexpression is a Novel Independent Prognostic Marker for Metastatic Ovarian Tumors[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2012,22(1):54-62.
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