IR@PKUHSC  > 北京大学第三临床医学院  > 骨科
学科主题临床医学
Effects of dihydroxylphenyl lactic acid on inflammatory responses in spinal cord injury
Chen, Xin1; Zhou, Changman2,5; Guo, Jun3,4; Sun, Kai2; Zhao, Na2; Yang, Jiying2; Sun, Yu1; Liu, Xiaoguang1; Hibi, Toshifumi4; Liu, Zhongjun1; Han, Jingyan2,3,4
关键词Spinal cord injury 3,4-dihydroxyphenyl lactic acid Inflammation I kappa B-alpha NF-kappa B
刊名BRAIN RESEARCH
2011-02-04
DOI10.1016/j.brainres.2010.11.089
1372页:160-168
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Tianjin Tasly group, Tianjin, China ; Tianjin Tasly group, Tianjin, China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NF-KAPPA-B ; NECROSIS-FACTOR-ALPHA ; MICROCIRCULATORY DISTURBANCE ; RAT MESENTERY ; TRANSCRIPTION FACTOR ; GENE-EXPRESSION ; AQUEOUS EXTRACT ; IMMUNE-SYSTEM ; ACTIVATION ; APOPTOSIS
英文摘要

The initial mechanical tissue disruption of spinal cord injury (SCI) is followed by a period of secondary injury that increases the size of the lesion. Secondary injuries are associated with edema, inflammation, excessive cytokine release, excitotoxicity and cell apoptosis. 3,4-dihydroxyphenyl lactic acid (DLA) is one of the major water-soluble components of chemical constituents from Salvia miltiorrhiza (SM). To investigate the inhibition effects of DLA on secondary injury of SCI, focusing especially on suppression of inflammatory responses and the mechanism of this effect, the following studies were performed: Basso, Beattie, and Bresnahan (BBB) scores to assess motor functions till 10 days after SCI; Nissl and Fast Blue histological staining and immunohistochemistry of inhibitory-kappa B-alpha (I kappa B-alpha) and nuclear factor-kappa B (NF-kappa B) p65 subunit protein; levels of myeloperoxidase (MPO) activity analysis as in indicator of polymorphonuclear infiltration; IL-6 production in plasma 10 days after SCI; Western blot analysis to determine cytoplasm levels of I kappa B-alpha and NF-kappa B p65 subunit proteins in the nuclear fractions 10 days after SCI. DLA significantly attenuated the motor function and tissue damage following SCI in rats, significant reduced polymorphonuclear cell infiltration and IL-6 production, as well as reduced cytoplasm I kappa B-alpha degradation and the nuclear translocation of NF-kappa B p65 subunit protein after SCI. In conclusion, the results clearly demonstrate that DLA inhibit the inflammation responses induced by SCI via inhibiting effect of production of IL-6 and nuclear translocation of NF-kappa B. (C) 2010 Published by Elsevier B.V.

语种英语
所属项目编号20050230
资助者Tianjin Tasly group, Tianjin, China ; Tianjin Tasly group, Tianjin, China
WOS记录号WOS:000287293700017
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60203
Collection北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Inst Spinal Surg, Dept Orthopaed, Hosp 3, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100083, Peoples R China
4.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
5.Peking Univ, Hlth Sci Ctr, Dept Anat & Histol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xin,Zhou, Changman,Guo, Jun,et al. Effects of dihydroxylphenyl lactic acid on inflammatory responses in spinal cord injury[J]. BRAIN RESEARCH,2011,1372:160-168.
APA Chen, Xin.,Zhou, Changman.,Guo, Jun.,Sun, Kai.,Zhao, Na.,...&Han, Jingyan.(2011).Effects of dihydroxylphenyl lactic acid on inflammatory responses in spinal cord injury.BRAIN RESEARCH,1372,160-168.
MLA Chen, Xin,et al."Effects of dihydroxylphenyl lactic acid on inflammatory responses in spinal cord injury".BRAIN RESEARCH 1372(2011):160-168.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Chen, Xin]'s Articles
[Zhou, Changman]'s Articles
[Guo, Jun]'s Articles
百度学术
百度学术Similar articles in
[Chen, Xin]'s Articles
[Zhou, Changman]'s Articles
[Guo, Jun]'s Articles
必应学术
必应学术Similar articles in
[Chen, Xin]'s Articles
[Zhou, Changman]'s Articles
[Guo, Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.