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学科主题: 临床医学
题名:
Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases
作者: Zheng, Lijun1; Wu, Xiaojiang2; Kreis, Martin E.3; Yu, Zhen1; Feng, Lijin4; Chen, Chunqiu1; Xu, Bin1; Bu, Zhaode2; Li, Ziyu2; Ji, Jiafu2
刊名: GASTROENTEROLOGY RESEARCH AND PRACTICE
发表日期: 2014
DOI: 10.1155/2014/202960
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: MALIGNANT SCHWANNOMA ; TUMORS ; STOMACH
英文摘要:

Schwannomas are tumors arising from the nervous system that also occur infrequently in the gastrointestinal tract, most commonly in the stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases with a median postoperative duration of 57 months. Clinicopathological and immunohistochemical characteristics of benign and malignant schwannomas were analysed. Four cases (13.7%) were histologically diagnosed with malignant schwannoma. All tumors were positive for S-100 and CD56 proteins, displaying a diffuse staining pattern. Vimentin was expressed in 100% cases and all schwannomas were negative for smooth muscle actin, c-kit, and HMB-45. A significant difference was observed between the group of benign and malignant schwannomas as regards recurrences and metastasis after complete resection (P = 0.015). The survival time of patients with benign schwannomas was longer than the malignant group (P = 0.013), so gastric malignant schwannomas have a potential for recurrence and metastasis, with subsequently short survival. Complete resection with an attempt to remove all tumor tissue with negative margins is of paramount importance in the management of gastric schwannomas, particularly when they turn out to be malignant.

语种: 英语
所属项目编号: 81170345 ; 12HBBD110
项目资助者: National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for cultivating tutor of doctor
WOS记录号: WOS:000331937300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60211
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Tongji Univ, Sch Med, Peoples Hosp Shanghai 10, Dept Gen Surg, Shanghai 200072, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing 100036, Peoples R China
3.Charite, Dept Gen Visceral & Vasc Surg, D-12200 Berlin, Germany
4.Tongji Univ, Sch Med, Peoples Hosp Shanghai 10, Dept Pathol, Shanghai 200072, Peoples R China

Recommended Citation:
Zheng, Lijun,Wu, Xiaojiang,Kreis, Martin E.,et al. Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases[J]. GASTROENTEROLOGY RESEARCH AND PRACTICE,2014.
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