IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases
Zheng, Lijun1; Wu, Xiaojiang2; Kreis, Martin E.3; Yu, Zhen1; Feng, Lijin4; Chen, Chunqiu1; Xu, Bin1; Bu, Zhaode2; Li, Ziyu2; Ji, Jiafu2
刊名GASTROENTEROLOGY RESEARCH AND PRACTICE
2014
DOI10.1155/2014/202960
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for cultivating tutor of doctor ; National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for cultivating tutor of doctor
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]MALIGNANT SCHWANNOMA ; TUMORS ; STOMACH
英文摘要

Schwannomas are tumors arising from the nervous system that also occur infrequently in the gastrointestinal tract, most commonly in the stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases with a median postoperative duration of 57 months. Clinicopathological and immunohistochemical characteristics of benign and malignant schwannomas were analysed. Four cases (13.7%) were histologically diagnosed with malignant schwannoma. All tumors were positive for S-100 and CD56 proteins, displaying a diffuse staining pattern. Vimentin was expressed in 100% cases and all schwannomas were negative for smooth muscle actin, c-kit, and HMB-45. A significant difference was observed between the group of benign and malignant schwannomas as regards recurrences and metastasis after complete resection (P = 0.015). The survival time of patients with benign schwannomas was longer than the malignant group (P = 0.013), so gastric malignant schwannomas have a potential for recurrence and metastasis, with subsequently short survival. Complete resection with an attempt to remove all tumor tissue with negative margins is of paramount importance in the management of gastric schwannomas, particularly when they turn out to be malignant.

语种英语
所属项目编号81170345 ; 12HBBD110
资助者National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for cultivating tutor of doctor ; National Science Foundation of China ; Shanghai Tenth People&prime ; s Hospital Project for cultivating tutor of doctor
WOS记录号WOS:000331937300001
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60211
Collection北京大学临床肿瘤学院
作者单位1.Tongji Univ, Sch Med, Peoples Hosp Shanghai 10, Dept Gen Surg, Shanghai 200072, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing 100036, Peoples R China
3.Charite, Dept Gen Visceral & Vasc Surg, D-12200 Berlin, Germany
4.Tongji Univ, Sch Med, Peoples Hosp Shanghai 10, Dept Pathol, Shanghai 200072, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Lijun,Wu, Xiaojiang,Kreis, Martin E.,et al. Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases[J]. GASTROENTEROLOGY RESEARCH AND PRACTICE,2014.
APA Zheng, Lijun.,Wu, Xiaojiang.,Kreis, Martin E..,Yu, Zhen.,Feng, Lijin.,...&Ji, Jiafu.(2014).Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases.GASTROENTEROLOGY RESEARCH AND PRACTICE.
MLA Zheng, Lijun,et al."Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases".GASTROENTEROLOGY RESEARCH AND PRACTICE (2014).
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