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Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation
Huang, Xiaoqiang1; Lia, Xinyao1; Jiao, Ning1,2
刊名CHEMICAL SCIENCE
2015
DOI10.1039/c5sc02126j
6期:11页:6355-6360
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]h Bond Functionalization ; Terminal Alkynes ; C-h ; Transition-metal ; Carboxylic-acids ; Alpha,Beta-acetylenic Ketones ; Efficient Synthesis ; Carbonyl-compounds ; Allenyl Azides ; Rearrangement
英文摘要

A novel direct transformation of aliphatic terminal alkynes to alkenyl nitriles through the incorporation of a nitrogen atom into the simple hydrocarbons has been reported. The usage of inexpensive copper catalyst, O-2 as the sole oxidant, broad substrate scope as well as feasibility for "late-stage modification" make this protocol very promising. Mechanistic studies including DFT calculation demonstrate a novel 1,2-hydride shift process for this novel nitrogenation reaction.

语种英语
WOS记录号WOS:000362977000040
通讯作者邮箱jiaoning@pku.edu.cn
项目编号2015CB856600 ; 21325206 ; 21172006
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60215
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714
Huang, Xiaoqiang,Lia, Xinyao,Jiao, Ning. Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation[J]. CHEMICAL SCIENCE,2015,6(11):6355-6360.
APA Huang, Xiaoqiang,Lia, Xinyao,&Jiao, Ning.(2015).Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation.CHEMICAL SCIENCE,6(11),6355-6360.
MLA Huang, Xiaoqiang,et al."Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation".CHEMICAL SCIENCE 6.11(2015):6355-6360.
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