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学科主题: 药学
题名:
Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation
作者: Huang, Xiaoqiang1; Lia, Xinyao1; Jiao, Ning1,2
刊名: CHEMICAL SCIENCE
发表日期: 2015
DOI: 10.1039/c5sc02126j
卷: 6, 期:11, 页:6355-6360
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: H BOND FUNCTIONALIZATION ; TERMINAL ALKYNES ; C-H ; TRANSITION-METAL ; CARBOXYLIC-ACIDS ; ALPHA,BETA-ACETYLENIC KETONES ; EFFICIENT SYNTHESIS ; CARBONYL-COMPOUNDS ; ALLENYL AZIDES ; REARRANGEMENT
英文摘要:

A novel direct transformation of aliphatic terminal alkynes to alkenyl nitriles through the incorporation of a nitrogen atom into the simple hydrocarbons has been reported. The usage of inexpensive copper catalyst, O-2 as the sole oxidant, broad substrate scope as well as feasibility for "late-stage modification" make this protocol very promising. Mechanistic studies including DFT calculation demonstrate a novel 1,2-hydride shift process for this novel nitrogenation reaction.

语种: 英语
所属项目编号: 2015CB856600 ; 21325206 ; 21172006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号: WOS:000362977000040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60215
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Huang, Xiaoqiang,Lia, Xinyao,Jiao, Ning. Copper-catalyzed direct transformation of simple alkynes to alkenyl nitriles via aerobic oxidative N-incorporation[J]. CHEMICAL SCIENCE,2015,6(11):6355-6360.
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