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学科主题: 临床医学
题名:
Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population
作者: Luo, Yingying1; Wang, Hongyuan2; Han, Xueyao1; Ren, Qian1; Wang, Fang1; Zhang, Xiuying1; Sun, Xiuqin1; Zhou, Xianghai1; Ji, Linong1
关键词: Meta-analysis ; Diabetes ; Type 2 ; TCF7L2
刊名: DIABETES RESEARCH AND CLINICAL PRACTICE
发表日期: 2009-08-01
DOI: 10.1016/j.diabres.2009.04.024
卷: 85, 期:2, 页:139-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: JAPANESE POPULATION ; SUSCEPTIBILITY GENE ; CHINESE POPULATION ; VARIANTS ; RISK ; POLYMORPHISMS ; REPLICATION
英文摘要:

Aims: To evaluate the effect of TCF7L2 on genetic susceptibility of type 2 diabetes (T2DM) in East Asian population by using the meta-analysis.

Methods: Search all the publications about the association between TCF7L2 and T2DM in East Asian population from PubMed, CNKI and abstracts of major diabetes conferences. Perform the meta-analysis of all the validated studies and evaluate the association between rs7903146 T allele, rs12255372 T allele, rs11196205 C allele, rs290487 C allele and rs11196218 G allele of TCF7L2 and the risk of T2DM.

Results: Eleven studies from nine eligible papers and one unpublished study of ours were included in the meta-analysis. Ten eligible studies were analyzed for rs7903146, five were analyzed for rs12255372 and rs11196205, and three were analyzed for rs290487 and rs11196218. We found that four SNPs (rs7903146, rs12255372, rs11196205, rs290487) in TCF7L2 were significantly associated with T2DM in East Asian populations. The rs11196218 also showed a marginal association. The estimated population-attributable risk (PAR) associated with analyzed SNPs ranged from 2% to 7%.

Conclusions: SNPs in TCF7L2 were strongly associated with the risk of T2DM in East Asian population. But the contribution of its genetic variants to the epidemic of type 2 diabetes in East Asian was relatively low. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30570873 ; 2006CB503900 ; 2006AA02A409
项目资助者: National Natural Science Fund of China ; National Basic Research Program of China ; 863 Program of China
WOS记录号: WOS:000268655800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60216
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100044, Peoples R China

Recommended Citation:
Luo, Yingying,Wang, Hongyuan,Han, Xueyao,et al. Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2009,85(2):139-146.
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