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学科主题: 基础医学
题名:
Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury
作者: Zhao, HB; Liu, SQ; Liu, JH; Lin, ZB
关键词: polysaccharide extract isolated from Ganoderma lucidum ; cultured rat cortical neuron ; hypoxia/reoxygenation
刊名: JOURNAL OF PHARMACOLOGICAL SCIENCES
发表日期: 2004-06-01
卷: 95, 期:2, 页:294-298
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SUPEROXIDE DISMUTASES ; IN-VITRO ; KAPPA-B ; ISCHEMIA ; DAMAGE ; CELLS ; STRESS
英文摘要:

The effect of polysaccharide extract isolated from Ganoderma lucidum (Gl-PS) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. Gl-PS (1, 10, 100 mug/ml) increased neuron viability following H/R as measured by the inhibition of MTT reduction. Gl-PS also significantly reduced malondialdehyde content and reactive oxygen species production and increased the manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B induced by H/R was blocked. These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury.

语种: 英语
WOS记录号: WOS:000222275700022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60221
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Fuzhou Green Valley Inst Biopharmaceut Technol, Fuzhou 350002, Peoples R China
3.Peking Univ, Confocal Microscope Lab, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, HB,Liu, SQ,Liu, JH,et al. Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2004,95(2):294-298.
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