IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury
Zhao, HB; Liu, SQ; Liu, JH; Lin, ZB
关键词polysaccharide extract isolated from Ganoderma lucidum cultured rat cortical neuron hypoxia/reoxygenation
刊名JOURNAL OF PHARMACOLOGICAL SCIENCES
2004-06-01
95期:2页:294-298
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SUPEROXIDE DISMUTASES ; IN-VITRO ; KAPPA-B ; ISCHEMIA ; DAMAGE ; CELLS ; STRESS
英文摘要

The effect of polysaccharide extract isolated from Ganoderma lucidum (Gl-PS) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. Gl-PS (1, 10, 100 mug/ml) increased neuron viability following H/R as measured by the inhibition of MTT reduction. Gl-PS also significantly reduced malondialdehyde content and reactive oxygen species production and increased the manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B induced by H/R was blocked. These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury.

语种英语
WOS记录号WOS:000222275700022
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60221
专题北京大学基础医学院_药理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Fuzhou Green Valley Inst Biopharmaceut Technol, Fuzhou 350002, Peoples R China
3.Peking Univ, Confocal Microscope Lab, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, HB,Liu, SQ,Liu, JH,et al. Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2004,95(2):294-298.
APA Zhao, HB,Liu, SQ,Liu, JH,&Lin, ZB.(2004).Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury.JOURNAL OF PHARMACOLOGICAL SCIENCES,95(2),294-298.
MLA Zhao, HB,et al."Polysaccharide extract isolated from Ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury".JOURNAL OF PHARMACOLOGICAL SCIENCES 95.2(2004):294-298.
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