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学科主题: 临床医学
题名:
A study of the functional significance of epidermal growth factor in major depressive disorder
作者: Tian, Wenmin1,2; Zhang, Juan1,2,3; Zhang, Kerang4; Yang, Hong4; Sun, Yan4; Shen, Yan1,2; Xu, Qi1,2
关键词: association study ; cis-phase interaction ; enzyme-linked immunosorbent assay ; epidermal growth factor ; gene expression ; major depressive disorder
刊名: PSYCHIATRIC GENETICS
发表日期: 2012-08-01
DOI: 10.1097/YPG.0b013e3283539550
卷: 22, 期:4, 页:161-167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Neurosciences
研究领域[WOS]: Genetics & Heredity ; Neurosciences & Neurology
关键词[WOS]: FACTOR A61G POLYMORPHISM ; NEUROTROPHIC FACTOR ; REGULATORY POLYMORPHISMS ; SERUM-LEVELS ; BDNF LEVELS ; RAT-BRAIN ; EXPRESSION ; ASSOCIATION ; EGF ; SCHIZOPHRENIA
英文摘要:

Objective The precise mechanism of major depressive disorder (MDD) is poorly understood. On the basis of the neurotrophin hypothesis, initial findings from our previous studies, and the functions of epidermal growth factor (EGF) in the central nervous system, we proposed that EGF might contribute to the development of MDD, which was investigated in this study.

Methods Eight single nucleotide polymorphisms (SNPs) within the EGF gene were genotyped in 463 patients with MDD and 413 control participants among a Chinese population; of these, the plasma EGF levels of 210 patients and 223 controls were determined using the enzyme-linked immunosorbent assay. To determine the effect of functional SNPs on EGF secretion in HEK293 cells, EGF levels in the supernatants of cultured cells were also assessed.

Results None of the informative SNPs showed an allelic association with MDD, but the cis-phase interaction between rs11569017 and rs11569126 was strongly associated with the illness (P=0.0027). The EGF levels in plasma were significantly lower in the patient group than in the control group (P<0.0001). The EGF levels were also significantly lower in patients with the rs11569017-TT genotype than those with either the AA genotype P=0.013) or the AT genotype (P=0.004); the rs11569017 minor allele significantly affected the expression of the EGF gene (P=0.0004).

Conclusion The cis-phase interaction between the SNPs within the EGF locus may contribute toward the etiology of MDD. The plasma EGF levels may be a useful biomarker for the early diagnosis, treatment, and prognosis of major psychiatric disorders. Psychiatr Genet 22:161-167 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 2010CB529603 ; 2006AA 02A 407 ; 121024 ; 30721063 ; 7102109
项目资助者: National Basic Research Program of China ; National 863 program ; Fok Ying Tong Education Foundation ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000306084500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60223
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing 100005, Peoples R China
2.Tsinghua Univ, Peking Union Med Coll, Beijing 100005, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Breast Ctr, Beijing 100871, Peoples R China
4.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China

Recommended Citation:
Tian, Wenmin,Zhang, Juan,Zhang, Kerang,et al. A study of the functional significance of epidermal growth factor in major depressive disorder[J]. PSYCHIATRIC GENETICS,2012,22(4):161-167.
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