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学科主题: 基础医学
题名:
LAPTM4B-35 Overexpression Is an Independent Prognostic Marker in Endometrial Carcinoma
作者: Meng, Fan-ling1; Yin, Ming-zhu1; Song, Hong-tao2; Yang, Hua3; Lou, Ge1; Zhou, Rou-li3
关键词: Lysosomal protein transmembrane 4 beta ; Immunohistochemistry ; Endometrial carcinoma ; Prognosis
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2010-07-01
DOI: 10.1111/IGC.0b013e3181e02f90
卷: 20, 期:5, 页:745-750
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; CANCER ; PROGRESSION ; EXPRESSION ; SURVIVAL ; PLAY
英文摘要:

Background: Lysosomal protein transmembrane 4 beta-35 (LAPTM4B-35), a novel oncoprotein that belongs to the mammalian 4-tetratransmembrane spanning protein superfamily, has been implicated in oncogenesis and cancer progression in several solid malignances. However, the expression of LAPTM4B-35 and its role in endometrial cancer progression remain unknown.

Materials and Methods: We investigated the expression of the LAPTM4B-35 protein by immunohistochemistry in 30 normal endometrium specimens and 165 endometrial carcinomas and analyzed its correlation with various clinicopathologic features, including patient outcome.

Results: LAPTM4B-35 immunoreactivity was overexpressed in endometrial carcinoma cases compared with normal endometrium (P < 0.001). High LAPTM4B-35 expression was found in 117 (70.91%) of these 165 carcinomas and was positively correlated with the International Federation of Gynecology and Obstetrics stage, histological grade, depth of myometrial invasion, lymph node metastasis, lymph vascular space involvement, and recurrence, but not with age and histological type. Patients with high LAPTM4B-35 expression had significantly poorer overall survival and disease-free survival compared with patients with low expression of LAPTM4B-35 (P = 0.001 and P = 0.002, respectively). Multivariate analysis showed that high LAPTM4B-35 expression was an independent prognostic factor for both overall survival and disease-free survival of patients with endometrial carcinoma (both P = 0.005).

Conclusions: These results showed that high LAPTM4B-35 expression was associated with progression and prognosis of endometrial carcinoma.

语种: 英语
WOS记录号: WOS:000280144000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60233
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
2.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150081, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China

Recommended Citation:
Meng, Fan-ling,Yin, Ming-zhu,Song, Hong-tao,et al. LAPTM4B-35 Overexpression Is an Independent Prognostic Marker in Endometrial Carcinoma[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2010,20(5):745-750.
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