|Association Study of the beta 2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese|
|Lou, Yuqing1,2; Liu, Jielin1,2; Li, Yao3; Liu, Ya1,2; Wang, Zuoguang1,2; Liu, Kuo1,2; Wu, Hai3; Niu, Qiuli1,2; Gu, Wei1,2; Guo, Yanhong4; Li, Zhizhong5; Wen, Shaojun1,2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||SINGLE-NUCLEOTIDE POLYMORPHISMS ; Y-CHROMOSOME EVIDENCE ; BETA(2)-ADRENERGIC RECEPTOR ; ADRENOCEPTOR POLYMORPHISMS ; HAPLOTYPE INFERENCE ; BLOOD-PRESSURE ; ADRB2 GENE ; POPULATION ; OBESITY ; COMBINATION|
Background: The beta 2-adrenergic receptor (ADRB2) gene has been widely researched as a candidate gene for essential hypertension (EH), but no consensus has been reached in different ethnicities. The aim of the present study was to evaluate the possible association between the ADRB2 gene polymorphisms and the EH risk in the Northern Han Chinese population.
Methodology/Principal Findings: This study included 747 hypertensive subjects and 390 healthy volunteers as control subjects in the Northern Han Chinese. Genotyping was performed to identify the C-47T, A46G and C79G polymorphisms of the ADRB2 gene. G allelic frequency of A46G polymorphism was significantly higher in hypertensive subjects (P = 0.011, OR = 1.287, 95% CI [1.059-1.565]) than that in controls. Significant association could also be found in dominant genetic model (GG+AG vs. AA, P = 0.006, OR = 1.497, 95% CI [1.121-1.998]), in homozygote comparison (GG vs. AA, P = 0.025, OR = 1.568, 95% CI [1.059-2.322]), and in additive genetic model (GG vs. AG vs. AA, P = 0.012, OR = 1.282, 95% CI [1.056-1.555]). Subgroup analyses performed by gender suggested that this association could be found in male, but not in female. Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95% CI [1.258-2.151]). Significant interaction was found between A46G genotypes and body mass index on EH risk. No significant association could be found between C-47T or C79G polymorphism and EH risk. Linkage disequilibrium was detected between the C-47T, A46G and C79G polymorphisms. Haplotype analyses observed that the T-47-A46-C79 haplotype was a protective haplotype for EH, while the T-47-G46-C79 haplotype increased the risk.
Conclusions/Significances: We revealed that the ADRB2 A46G polymorphism might increase the risk for EH in the Northern Han Chinese population.
|项目编号||2008AA02Z441 ; 2008BAI52B03|
|资助机构||National High Technology Research and Development Program ; Ministry of Science and Technology of the People&prime ; s Republic of China|
|作者单位||1.Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China|
2.Capital Med Univ, Beijing Anzhen Hosp, Dept Hypertens Res, Beijing, Peoples R China
3.Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
4.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
5.Capital Med Univ, Beijing Anzhen Hosp, Emergency Ctr Heart Lung & Blood Vessel Dis, Beijing, Peoples R China
|Lou, Yuqing,Liu, Jielin,Li, Yao,et al. Association Study of the beta 2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese[J]. PLOS ONE,2011,6(4).|
|APA||Lou, Yuqing.,Liu, Jielin.,Li, Yao.,Liu, Ya.,Wang, Zuoguang.,...&Wen, Shaojun.(2011).Association Study of the beta 2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese.PLOS ONE,6(4).|
|MLA||Lou, Yuqing,et al."Association Study of the beta 2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese".PLOS ONE 6.4(2011).|