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学科主题基础医学
Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains
Feng, Q; Yu, H; Liu, YY; He, CQ; Hu, JS; Sang, HC; Ding, NZ; Ding, MX; Fung, YWW; Lau, LT; Yu, ACH; Chen, JG
关键词picornavirus serotype phylogenesis sequence alignment
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2004-10-08
DOI10.1016/j.bbrc.2004.08.086
323期:1页:254-263
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NEUTRALIZING ANTIGENIC SITES ; COMPLETE NUCLEOTIDE-SEQUENCE ; DEPENDENT RNA-POLYMERASE ; CELL RECOGNITION ; LEADER PROTEIN ; GENE SEQUENCE ; HONG-KONG ; APHTHOVIRUS ; POLIOVIRUS ; BINDING
英文摘要

The genome of a novel foot-and-mouth disease virus, HKN/2002, was 8104 nucleotides (m) in length (excluding the poly(C) tract and poly(A) tail) and was composed of a 1042-nt 5′-untranslated region (UTR), a 6966-nt open reading frame, and a 93-nt 3′-UTR. Genome sequences of HKN/2002 and other known FMDV strains were compared. The VP1, VP2, and VP3-based neighbor-joining (NJ) trees were divided into distinct clusters according to different serotypes, while other region-based NJ trees exhibited some degree of intercross among serotypes. Mutations in HKN/2002 were revealed, including frequent deletions and insertions in the G-H loop of VP1, and deletion involving 10 amino acid residues in the 3A protein. An evolutionary relationship of HKN/2002 with an Asian FMDV lineage isolated from a Hong Kong swine host in 1970 was postulated. A 43-nt deletion identified in the 5′-UTR of HKN/2002 possibly contributed to the loss of one pseudo-knot domain. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000223965300039
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60240
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
2.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Coll Life Sci, Dept Cell Biol & Genet, Beijing 100871, Peoples R China
4.Peking Univ, Sch Math Sci, Dept Probabil & Stat, Beijing 100871, Peoples R China
5.Peking Univ, Minist Educ, Neurosci Res Inst, Key Lab Neurosci,Dept Neurobiol, Beijing 100083, Peoples R China
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GB/T 7714
Feng, Q,Yu, H,Liu, YY,et al. Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,323(1):254-263.
APA Feng, Q.,Yu, H.,Liu, YY.,He, CQ.,Hu, JS.,...&Chen, JG.(2004).Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,323(1),254-263.
MLA Feng, Q,et al."Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 323.1(2004):254-263.
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