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Effect of polymorphisms in the beta 2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: a meta analysis
Niu Li-ming1; Liang Ying1; Xu Ming2,3; Zhang You-yi2,3; Zhang Yuan1; He Bei1
关键词meta-analysis beta2-adrenergic receptor chronic obstructive pulmonary disease polymorphism susceptibility pulmonary Junction
刊名CHINESE MEDICAL JOURNAL
2012-06-20
DOI10.3760/cma.j.issn.0366-6999.2012.12.023
125期:12页:2213-2218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education ; National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education
研究领域[WOS]General & Internal Medicine
关键词[WOS]BETA(2)-ADRENERGIC RECEPTOR ; GENETIC POLYMORPHISMS ; ASTHMATIC SUBJECTS ; LUNG-FUNCTION ; ADRB2 GENES ; COPD ; ASSOCIATION ; MUTATIONS
英文摘要

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex disease of which the pathogenesis remains largely unknown. Many factors could influence COPD development and progression. One of them is the genetic risk factor. A severe hereditary deficiency of alpha-1 antitrypsin is the best genetic proof. Four single nucleotide polymorphisms (SNPs) of beta2-adrenergic receptor (beta(2)AR) result in single amino acid substitution. Two loci had been extensively studied and found that they could change the function of beta(2)AR. Two SNPs consist of substitutions of glycine for arginine at amino acid position 16, glutamic acid for glutamine at position 27. Many studies proved that polymorphisms at position 16 and 27 altered the lung function of COPD patients or the patient′s susceptibility to the development of COPD. However, there was no exclusive conclusion. Therefore, a meta analysis was done to investigate the effect of polymorphisms in the beta 2-adrenergic receptor (ADRB2) gene on the risk of COPD and lung function.

Methods Comprehensive searches of MEDLINE, Embase, Ovid, HighWire, Cochrane Library, and Chinese databases (CBMdisc, VIP, CNKI, and Wanfang data) from January 1980 to September 2011 were performed, using the keywords: COPD OR chronic obstructive pulmonary disease AND adrenoreceptor OR adrenergic receptor AND polymorphism OR mutation OR variation. Case-control research or cross sectional studies in which diagnosis of COPD met the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines; all the studies reported the ADRB2 genotype at position 16 or 27. Outcomes measured were genotype frequency and forced expiratory volume in the first second (FEV1%) in both the case and control.

Results Twelve case-control studies and eight cross-sectional studies were included. Compared to the control (n=1225), neither Gly/Gly (n=527) nor Arg/Arg (n=422) homozygotes at position 16 demonstrated increased susceptibility to COPD, with odds ratios (ORs) of 0.95 (95% CI (0.68, 1.31), z=0.33, P=0.740) and 0.82 (95% CI (0.52, 1.28), z=0.88, P=0.381), respectively. Similar results were obtained for position 27, with ORs of 0.97 (95% CI (0.77, 1.23), z=0.21, P=0.833) for Glu/Glu homozygotes (n=357) and 0.82 (95% CI (0.53, 1.29), z=0.85, P=0.393) for Gln/Gln homozygotes (n=704) (control=1183). In patients with COPD, Arg/Arg homozygotes (n=41) had a similar FEV1% compared with Gly/Gly homozygotes (n=102) (standardized mean difference (SMD)=0.88, 95% CI (-0.85, 2.62), z=1.00, P=0.319). The genotype distribution was different between Caucasian and Asian populations (all P <0.05 except the genotype Arg/Gly) for both position 16 and 27.

Conclusions Polymorphisms of ADRB2 at positions 16 and 27 did not change the risk of COPD nor affect lung function or disease severity. The genotype distribution for these polymorphisms was different between Caucasian and Asian populations. Chin Med J 2012;125(12):2213-2218

语种英语
所属项目编号30770939 ; 20090001110093
资助者National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education ; National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education
WOS记录号WOS:000306382400023
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60243
专题北京大学第三临床医学院_呼吸科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Resp Dis, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Inst Vasc Med, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Niu Li-ming,Liang Ying,Xu Ming,et al. Effect of polymorphisms in the beta 2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: a meta analysis[J]. CHINESE MEDICAL JOURNAL,2012,125(12):2213-2218.
APA Niu Li-ming,Liang Ying,Xu Ming,Zhang You-yi,Zhang Yuan,&He Bei.(2012).Effect of polymorphisms in the beta 2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: a meta analysis.CHINESE MEDICAL JOURNAL,125(12),2213-2218.
MLA Niu Li-ming,et al."Effect of polymorphisms in the beta 2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: a meta analysis".CHINESE MEDICAL JOURNAL 125.12(2012):2213-2218.
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